Systematic Review of the Pharmacological Evidence for the Selection of Antimicrobials in Bacterial Infections of the Central Nervous System in Dogs and Cats.

Bacterial meningitis in dogs and cats is a rare disease associated with a high lethality rate. The spectrum of causative bacteria includes a diverse set of gram positive, gram negative and anaerobic species. Currently, no veterinary medicinal product is approved for this indication in these species in Europe. The objective of this review was to collect the available pharmacokinetic data for antibiotics approved in dogs and cats to enable a preliminary analysis of their potential effectiveness for the treatment of bacterial meningitis. This analysis yielded data for 13 different antibiotics in dogs and two in cats. Additionally, data about frequently recommended cephalosporines not approved in dogs and cats were included. The collected data was used to assess the potential of the respective antibiotics to attain certain simple pharmacokinetic-pharmacodynamic (PK-PD) indexes in the cerebrospinal fluid (CSF). A more sophisticated investigation using modern methods was not possible due to the limited data available. For this purpose, data about the sensitivity of four bacterial species commonly associated with meningitis in dogs and cats to these antibiotics were included. The analysis provided evidence for the potential effectiveness of ampicillin, doxycycline, enrofloxacin, ceftriaxone and cefoxitin against bacteria frequently detected in bacterial meningitis in dogs. Data were not available or insufficient for the assessment of several antibiotics, including frequently recommended substances like metronidazole and trimethoprim-sulphonamide. Little evidence is available for the use of antibiotics in cats afflicted with this disease, highlighting the need for further research to obtain data for evidence based therapeutic recommendations.

[Antidoping rules in equine sports and pharmacological aspects of rule-consistent medical treatment and feeding of sport horses]. / Anti-Doping-Regeln im Pferdesport und pharmakologische Aspekte der regelkonformen Therapie und Fütterung von Sportpferden.

Veterinarians play an essential role in the prevention of doping in equine sports, both as attending clinicians as well as official competition veterinarians. This complex task requires comprehensive knowledge concerning the pertinent regulations. These include official laws, such as the animal protection and medicines laws as as well as rules issued by the responsible equine sports authority. Furthermore, veterinarians are required to determine adequate withdrawal times following the legitimate use of medications in sport horses. This may be performed by applying appropriate data published by the respective equestrian sports authorities. In case such data is not available, pharmacokinetic heuristics elucidated in this article may be utilized in order to define suitable withdrawal times. Furthermore, veterinarians are recommended to advise horse owners concerning the risk of feed contaminants that may cause inadvertent positive anti-doping samples. In this context, the prevention of botanical contaminations in roughage is of importance in central Europe. Official veterinarians fulfil the task of anti-doping sampling during competitions. In order to guarantee a correct procedure, precautions for the avoidance of sample contamination are warranted and correct identification of the samples must be ensured. These procedures are described by means of the rules of the German Equestrian Federation.

Systematic analysis to assess the scientific validity of the international residue limits for caffeine and theophylline in horse-racing.

Based on their performance-enhancing potential, caffeine and theophylline are prohibited substances in equine sports. Residues in horses can be caused by wilful application or by unintended uptake of contaminated feed. The International Federation of Horseracing Authorities recently introduced international residue limits (IRLs) to facilitate the discrimination between pharmacological relevant and irrelevant concentrations in doping samples. The objective of this study was to investigate the scientific validity of these IRLs. A systematic analysis was performed to assess the IRLs by different statistical approaches using published pharmacokinetic data. 31 out of 218 potentially relevant publications met the inclusion criteria. Thereby, both IRLs were found to be appropriate for the exclusion of the presence of a relevant pharmacological effect after a wilful application. The IRL of theophylline was also determined to be suitable for the prevention of positive doping tests caused by the ingestion of contaminated feed. In contrast, the IRL of caffeine is not suitable to prevent positive doping test caused by the ingestion of more than 10 mg caffeine per day per horse with contaminated feed. The lack of corresponding regulation for paraxanthine, a major active metabolite of caffeine and theophylline, was recognised as a substantial shortcoming of the current system, rendering both IRLs incomplete.