ABSTRACT
The authors describe the significant rise in the percentage of erythrocytes containing fetal hemoglobin during the course of morbus haemolyticus neonatorum.
Subject(s)
Erythroblastosis, Fetal/blood , Fetal Hemoglobin/metabolism , Anemia, Neonatal/blood , Erythrocytes/metabolism , Humans , Infant, NewbornABSTRACT
Using a simplified radioimmunoassay method for the determination of 17-hydroxyprogesterone (17-OHP) concentration in blood dried on filter paper seven untreated cases of congenital adrenal hyperplasia were identified among newborns and infants at risk for congenital adrenal hyperplasia (CAH) having ambiguous genitalia and/or failure to thrive with electrolyte disturbances. In three additional cases the diagnosis of congenital adrenal hyperplasia was confirmed by high 'dot-17-OHP' values even after glucocorticoid therapy had been started. Capillary blood samples taken in a local hospital on a filter paper routinely used for the screening of phenylketonuria can be sent by mail into a central laboratory for performing the analysis. Assays of 'dot-17-OHP' are clearly of diagnostic value in the C21-hydroxylase form of CAH and permit a rapid diagnosis of this condition in the newborn period.
Subject(s)
Adrenal Hyperplasia, Congenital/blood , Radioimmunoassay/methods , Female , Glucocorticoids/therapeutic use , Humans , Hydroxyprogesterones , Infant, Newborn , Male , RiskSubject(s)
Disseminated Intravascular Coagulation/etiology , Hemangioendothelioma/congenital , Infant, Newborn, Diseases/congenital , Cobalt Radioisotopes/therapeutic use , Disseminated Intravascular Coagulation/complications , Hemangioendothelioma/complications , Hemangioendothelioma/radiotherapy , Hematoma/etiology , Humans , Infant, Newborn , Male , Radioisotope Teletherapy , Thigh/blood supplySubject(s)
Infant, Newborn, Diseases/diagnosis , Toxoplasmosis, Congenital/diagnosis , Autopsy , Brain/parasitology , Brain/pathology , Brain Neoplasms/diagnosis , Diagnosis, Differential , Humans , Infant, Newborn , Infant, Newborn, Diseases/immunology , Infant, Newborn, Diseases/parasitology , Serologic Tests , Toxoplasmosis, Congenital/immunology , Toxoplasmosis, Congenital/pathologyABSTRACT
The authors present the first case of congenital toxoplasmosis mimicking a cerebral tumor. Serological reactions and special features of congenital toxoplasmosis relevant to diagnosing in this disease are discussed. Trials to prevent congenital toxoplasmosis as quoted from the literature are reviewed.
Subject(s)
Pseudotumor Cerebri/etiology , Toxoplasmosis, Congenital/complications , Autopsy , Humans , Infant , Infant, Newborn , Male , Pseudotumor Cerebri/pathology , Toxoplasmosis, Congenital/pathologySubject(s)
Blood Group Antigens , Blood Group Incompatibility , Duffy Blood-Group System , Erythroblastosis, Fetal/immunology , Hemolysis , Puerperal Disorders/immunology , Exchange Transfusion, Whole Blood , Female , Humans , Infant, Newborn , Isoantibodies , Pregnancy , Rh-Hr Blood-Group System , Transfusion ReactionABSTRACT
Cochlear- and vestibular function were investigated in 72 patients, aged between 4 and 7 years who had neonatal hyperbilirubinaemia. Markedly more and more serious damage was found in the group of patients, who as neonates had serum bilirubin levels above 25 mg-%. The frequency of loss of cochlear and vestibular function was significantly higher in patients with hyperbilirubinaemia for more than 4 days. Contrary to data published until now, it can be concluded that the vestibular apparatus is the most sensitive part of the nervous system to bilirubin.
Subject(s)
Erythroblastosis, Fetal/diagnosis , Hearing Disorders/complications , Vestibular Function Tests , Audiometry , Child , Child, Preschool , Erythroblastosis, Fetal/complications , Exchange Transfusion, Whole Blood , Female , Humans , Pregnancy , Time FactorsABSTRACT
In 30 newborns the blood sugar level was determined before and after exchange transfusion. At the end of exchange transfusion, the blood sugar reached in each case 200 mg-% or more, but with in one hour fell back to the starting level. If the patient did not get an adequate quantity of sugar during that time, hypoglycaemia developed. It is known, that patients with severe haemolytic disease have hyperinsulinism, but we investigated only such patients, who were born with Hgfv levels above 10 g-%. Therefore, it seems, that the hypoglycaemia in those cases is not due to the haemolytic disease, but a reaction to the sugar, given with the ACD blood.
Subject(s)
Exchange Transfusion, Whole Blood/adverse effects , Hypoglycemia/etiology , Infant, Newborn, Diseases/etiology , Blood Glucose/metabolism , Humans , Infant, Newborn , Time FactorsABSTRACT
The changes of acid-base values of 60 mature and premature neonates treated by exchange transfusion were followed. It could be shown that the blood conserves having acidic pH values caused no acidosis if the acid-base balance of the patients had been normal before transfusion. An existing acidosis frequently increased significantly in the first day of life of the mature but also in the later days in premature neonates. Thus, the determination of acid-base state prior and after transfusion of such patients seems to be important. In the case of pronounced acidosis its correction and also the control of the acid-base values after the exchange transfusion are necessary.
