1.
Bioorg Med Chem Lett
; 10(18): 2075-8, 2000 Sep 18.
Article
in English
| MEDLINE
| ID: mdl-10999474
ABSTRACT
A QSAR study, involving the use of calculated physical properties (TSAR), and the use of a neural network approach (TSAR), has been performed concerning the anti-HIV activity and cytotoxic effects of a series of d4T phosphoramidate derivatives with varying L-alanine esters. Models were obtained which allow reliable predictions for the anti-HIV activity, and cytotoxicity, of these derivatives.