ABSTRACT
Abrin is a toxin of public health concern due to its lethality, lack of antidote, and potential for use as a bioterrorism agent. Possible routes of exposure include ingestion, inhalation, and injection. Onset of symptoms is often delayed, even in severe cases. In fatal cases, death occurs from multi-organ failure. We describe the clinical course, laboratory, and pathologic findings in a case of fatal human poisoning associated with abrin injection. The Abrus precatorius seeds in this case were obtained via the internet. The Centers for Disease Control and Prevention's Laboratory Response Network detected abrine in the urine confirming abrin exposure in this fatal poisoning.
Subject(s)
Abrin/poisoning , Adult , Fatal Outcome , Humans , Injections , MaleABSTRACT
Groundwater in the Todos Santos watershed in southern Baja California, and throughout the peninsula south of latitude 28°N, has values of (δ18 O, δD) ranging between (-8.3, -57) and (-10.9, -78). Such negative values are uncharacteristic of the site latitude near the sea level. Altitude effects do not explain the isotope data. Tropical depressions originating along the Pacific coast of North America yield rain with isotopic depletion; rain from these weather systems in southern Arizona commonly has δ18O values<-10 in comparison with amount-weighted mean summer and fall rain at -6. Isotope data indicate hurricane rain as the predominant source of recharge in southern Baja California, where named tropical depressions bring large rains (>50 mm) at least once every 2 to 3 years, and along the Pacific coast between Jalisco and Oaxaca.