ABSTRACT
The authors report two cases of sclerosing lipogranuloma of the scalp diagnosed postmortem. The first was suspected to have acquired the lipid material from a grease gun injury to the scalp, while the second had received injections of an unidentified lipid for treatment of baldness. In each, the resultant sclerosing lipogranuloma extended laterally beneath the scalp from the vertex of the skull. The histologic reaction was round to oval cystic spaces within a dense collagenous stroma typical of the "swiss cheese" pattern of sclerosing lipogranuloma. Punctate, ringlike, or globoid densities were seen on roentgenograms of a 5-mm-thick transmural section of scalp in the first case.
Subject(s)
Granuloma/pathology , Lipids/adverse effects , Scalp Dermatoses/pathology , Granuloma/chemically induced , Humans , Male , Middle Aged , Scalp Dermatoses/chemically induced , SclerosisABSTRACT
We examined the ultrastructure of the spleen surgically removed from a patient with the in vivo diagnosis of malignant histiocytosis. The findings showed sinuses greatly dilated and lined by large atypical histiocytic cells. Erythrophagocytosis was prominent. These findings, as well as the histologic features of the bone marrow and later autopsy specimens, confirmed the diagnosis of malignant histiocytosis. The somewhat unusual confinement of histiocytes to sinusoids raised the possibility that this may represent a rare subvariant, histiocytic sinus reticulosis, first described by Robb-Smith in his original paper.
