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Bioorg Med Chem Lett
; 14(18): 4623-6, 2004 Sep 20.
Article
in English
| MEDLINE
| ID: mdl-15324876
ABSTRACT
The synthesis and SAR studies of spiroquinazolinones as novel PDE7 inhibitors are discussed. The best compounds from the series displayed nanomolar inhibitory affinity and were selective versus other PDE isoenzymes.