ABSTRACT
The records of 54 labrador retrievers with idiopathic epilepsy were reviewed. Exogenous factors played a minor role in the transmission of the epilepsy. Prodromal phase and aura were present in the majority of the dogs with generalised seizures. The ictal phase was characterised by long-lasting automatisms. Approximately half of the dogs had seizures more than once a month: the remainder ranged from one every two months to one every 12 months. The average frequency in dogs with generalized seizures (n = 49) was one every 65 days and in dogs with partial seizures (n = 5) one every 205 days. Long-term follow-up was performed in 46 dogs, 37 of which followed a strict treatment protocol. Possible causes for the large variations in treatment results were analysed. One goal was to identify objective aspects enabling a realistic prognosis prior to treatment. Animals with a high age at onset of seizure (mean, four years) showed an excellent outcome, even if treatment began late. Dogs with low frequency rates and low total numbers of seizures responded well to therapy if treated as early as possible.
Subject(s)
Anticonvulsants/therapeutic use , Dog Diseases/drug therapy , Dog Diseases/epidemiology , Epilepsy/veterinary , Phenobarbital/therapeutic use , Administration, Oral , Animals , Anticonvulsants/administration & dosage , Anticonvulsants/blood , Dog Diseases/etiology , Dogs , Epilepsy/drug therapy , Epilepsy/epidemiology , Female , Follow-Up Studies , Male , Phenobarbital/administration & dosage , Phenobarbital/blood , Prevalence , Prognosis , Seizures/etiology , Seizures/physiopathology , Seizures/veterinary , Time Factors , Treatment OutcomeABSTRACT
The clinical research results on idiopathic epilepsy (IE) in the dog performed at the Institute of Animal Neurology in Berne between the years 88-95 are presented. Special emphasis was placed on the genetic and electroencephalographic aspects obtained from large, uniform dog populations. We showed that IE affects all dogs of different ages. Although the clinical manifestation of seizure activity included different seizure types, a breed-specific seizure expression was found in the Retriever dog. Furthermore the use of interictal electroencephalography in the confirmation of IE was demonstrated. The results of a long-term treatment study with Phenobarbital in 46 Labrador Retrievers with IE are reported. In addition, the genetical and epidemiological aspects of the disease in each a large Golden and Labrador Retriever dog population were analysed.
