1.
Nucleosides Nucleotides Nucleic Acids
; 20(4-7): 1169-72, 2001.
Article
in English
| MEDLINE
| ID: mdl-11562979
ABSTRACT
Replacing the sugar-phosphodiester backbone of nucleic acids with a pyrrolidine-amide backbone results in an oligonucleotide mimic POM 1 which binds with high affinity and specificity to complementary DNA and RNA. Unlike other modified oligonucleotides, POM binds much more rapidly to single stranded RNA than DNA.