ABSTRACT
The monkeypox (mpox) outbreak that began in May 2022 spread globally with a wide range of presentations. Mpox proctitis has been recognized as one of the severe forms of the virus during this outbreak. We present the case of a 33-year-old male with well-controlled HIV engaging in receptive anal intercourse presented with profuse rectal bleeding, tenesmus, and anal pain in July 2022. His symptoms persisted despite treatment for his rectal chlamydia with doxycycline. Rectal imaging with computed tomography demonstrated impressive inflammation. Contrast-enhanced images highlighted rectal wall thickening and submucosal edema. Diffuse lymphadenopathy of the anorectal region was also clearly seen. He received symptomatic treatment with tecovirimat resulting in the resolution of his symptoms and complaints. Subsequent rectal imaging displayed improvement and decreased inflammation. A better understanding of various presentations, imaging characteristics, and management is necessary to curb further dissemination.
ABSTRACT
OBJECTIVES: The objectives of this pilot study were to analyze the electromyography (EMG) activity of masseter and anterior temporalis muscles during chewing in 2 different posture conditions: natural head posture (NHP) and maximum yet comfortable forward head posture (FHP) in healthy individuals; and to compare EMG activity between subjects based on their NHP during chewing. METHODS: Fifteen subjects participated. Sagittal head posture in sitting position was clinically assessed using a plumb line. Participants were classified as having FHP or upright head posture (UP). Surface EMG was used to evaluate superficial masseter and anterior temporalis bilaterally during chewing in NHP and FHP. Three trials with five chewing cycles were recorded. EMG data were normalized using a maximum voluntary contraction. An independent t-test was used to calculate differences between sides. If no differences were found, both sides were analyzed together. To analyze differences between the 2 conditions, a paired t-test was used. Independent t-test was used to calculate difference between subjects with UP and FHP. RESULTS: A significant increase in muscle activity was found for masseter muscle in the FHP condition. No differences were found in muscle activity in natural head position by posture classification. A trend of increased activity was observed for masseter and temporalis muscles during chewing in FHP. CONCLUSION: Head and neck posture was found to influence masticatory muscle activity during the function of chewing. The results of this study may help clinicians to better understand the association between head and neck posture alterations with masticatory muscles related disorders.
ABSTRACT
Concerns have been raised regarding the potential for endocrine disrupting compounds (EDCs) to alter brain development and behavior. Developmental exposure to bisphenol A (BPA), a ubiquitous EDC, has been linked to altered sociosexual and mood-related behaviors in various animal models and children but effects are inconsistent across laboratories and animal models creating confusion about potential risk in humans. Exposure to endocrine active diets, such as soy, which is rich in phytoestrogens, may contribute to this variability. Here, we tested the individual and combined effects of low dose oral BPA and soy diet or the individual isoflavone genistein (GEN; administered as the aglycone genistin (GIN)) on rat sociosexual behaviors with the hypothesis that soy would obfuscate any BPA-related effects. Social and activity levels were unchanged by developmental exposure to BPA but soy diet had sex specific effects including suppressed novelty preference, and open field exploration in females. The data presented here reinforce that environmental factors, including anthropogenic chemical exposure and hormone active diets, can shape complex behaviors and even reverse expected sex differences.
