[Amoxicillin in association with clavulanic acid in the treatment of urinary infection in children]. / Amoxicilina más ácido clavulánico en el tratamiento de las infecciones urinarias en pediatría.

Fifty-eight paediatric patients aged one month to 14 years, who met the inclusion criteria for urinary infection, were studied. They were administered amox/clav at a dose of 21.9 +/- 2.96 (mean +/- SD) mg/kg/day for ten days. E. coli was isolated in 53 cases, P. mirabilis in two, K. pneumoniae in two and E. cloacae in one. Of the E. coli, 94.34% were sensitive to amox/clav, 67.92% were resistant to ampicillin, three cases showed intermediate sensitivity and the case of E. cloacae was resistant. These four patients were withdrawn from the study, and four more who did not come for follow-up. Of the 50 assessable patients, 94% were cured. Three days after completing the treatment, three patients (6%) still had a positive uroculture, although only one showed symptoms. Of the remaining 47, five cases (11%) presented bacteriological relapse in the culture made seven days later. Only 10% of the patients showed any type of gastrointestinal disturbances, and interruption of treatment was not necessary. The amox/clav combination, in view of its broad spectrum, easy administration by oral route and good tolerance, should be taken into account as a first choice treatment in urinary infections in paediatric patients of any age.

[Acute osteomyelitis in childhood. Review of 66 cases]. / Osteomielitis aguda en la infancia. Revisión de 66 casos.

66 cases of acute osteomyelitis have been reviewed. The results obtained have been compared with those shown in the literature. There was a large predominance of males. Hematogenous inoculation was the most frequent. Clinical manifestations have been typical in children and polymorphic in infants and neonates. Leukocytosis with left deviation and elevated ESR, were frequent gammagraphic bone scan was positive in 88% of the cases so explored. The etiologic agents were isolated in 71% of the cases from blood cultures and needle aspiration from subperiosteal space and/or joint fluid cultures. S. aureus was found in 57.4% of all cases and in 86.4% of older children. The sequelae have been more frequent in neonates and infants.