1.
Org Biomol Chem
; 7(21): 4481-90, 2009 Nov 07.
Article
in English
| MEDLINE
| ID: mdl-19830299
ABSTRACT
Preparation of several acyclonucleosides containing both a difluoromethylphosphonate group and a triazole moiety is described starting from a difluorophosphonosulfide. The key step of the synthesis involves a copper(I)-catalyzed Huisgen 1-3 dipolar cycloaddition between difluorophosphonylated azides and propargylated nucleobases derived from thymine and 2-amino-6-chloropurine.