ABSTRACT
Children living in poverty are vulnerable to the adverse effects associated with unmet basic needs, such as food and housing. Poverty threatens the overall growth and development of children placing them at risk for poor cognitive, behavioral, and psychological outcomes. Addressing social determinants of health in the pediatric primary care setting is within the role of the pediatric primary care provider. The Model for Improvement guided this quality improvement project in the implementation of food and housing insecurity screening during well-child appointments in a rural health clinic.
Subject(s)
Health Personnel/standards , Mass Screening/standards , Practice Guidelines as Topic , Primary Health Care/standards , Quality Improvement/standards , Rural Health Services/standards , Social Determinants of Health/standards , Appointments and Schedules , Child, Preschool , Female , Food Supply/statistics & numerical data , Housing/statistics & numerical data , Humans , Infant , Male , Poverty , United StatesABSTRACT
The objective of this study was to identify predictors of self-reported family health history of breast cancer in an ethnically diverse population of women participating in a breast cancer screening program. Participants completed a self-administered questionnaire about their demography, health, breast health and family health history of breast cancer. The association between family health history of breast cancer and categorical variables were analyzed using the T test, chi square, and multi-nominal logistic regression. Those who were least likely to report a family history of cancer were African Americans (p = 0.02), and immigrant women from South America (p < 0.001) and Africa (p = 0.04). However, 34.4 % reported having a second-degree maternal relative with breast cancer compared to 6.9 % who reported having a second degree paternal relative with breast cancer. Therefore, there is a need to increase efforts to educate families about the importance of collecting and sharing one's family health history.
Subject(s)
Breast Neoplasms/ethnology , Breast Neoplasms/genetics , Genetic Predisposition to Disease/ethnology , Medical History Taking/methods , Self Report , Adult , Aged , Aged, 80 and over , Emigrants and Immigrants/psychology , Female , Health Knowledge, Attitudes, Practice , Health Literacy , Humans , Logistic Models , Medical History Taking/standards , Middle Aged , Socioeconomic FactorsABSTRACT
PURPOSE: Preclinical models showed TAC-101 (4-[3,5-bis(trimethylsilyl) benzamide] benzoic acid), an oral synthetic retinoid, has anti-tumor activity in hepatocellular carcinoma (HCC). A phase I/II study was performed in advanced HCC patients (pts). PATIENTS AND METHODS: Thirty-three patients were enrolled. During Phase I, pts received 40 mg daily for 14 days q3 weeks; 2 of 5 patients developed DLT so dose was reduced to 20 mg/day. Twenty-eight patients received 20 mg/day. RESULTS: No pt had a CR or PR, but 12 of 21 (57%) had SD. Two pts (9.5%) had late PR after discontinuing TAC-101. Median survival (MS) for all 28 pts treated with 20 mg/day was 12.7 months (95% CI 8.8-22.7); MS for 21 evaluable pts was 19.2 months (95% CI 10.4-27.6). CONCLUSIONS: 20 mg of TAC- was well tolerated. Significant disease stabilization (12/21 pts, 57%), 2 late PRs, and prolonged MS (19.2 months) suggest that TAC-101 provides meaningful patient benefit.
