Subject(s)
Pregnancy Complications , Wounds and Injuries , Female , Fetal Monitoring , Humans , PregnancyABSTRACT
The incidence of high-risk conditions complicating pregnancy is greater than one would suspect. Many times a pregnancy does not become high risk until labor starts. Prehospital and Emergency Department protocol should be directed at getting the mother to the labor and delivery suite as soon as possible. Most complications resulting in maternal-fetal morbidity and mortality are handled best in that setting. Prehospital and Emergency Department personnel should, however, be prepared to handle imminent delivery because it cannot be avoided when it occurs. Emergency Department personnel also should be familiar with the technique of perimortem cesarean delivery and use this technique when indicated for fetal-maternal salvage.
Subject(s)
Delivery, Obstetric/methods , Emergency Medical Services , Pregnancy Complications/therapy , Cesarean Section , Death , Emergency Service, Hospital , Female , Fetal Monitoring , Humans , Infant, Newborn , Obstetric Labor Complications/therapy , Pregnancy , Prognosis , Risk Factors , TriageABSTRACT
Modification of the 1,4-benzodioxan ring present in RX 781094 has not previously been considered. This paper describes a number of analogues of this ring system, including compounds in which one of the oxygen atoms has been replaced by a methylene group and also those in which the ring size has been changed to give, for example, furan and thiophene derivatives. The dihydrobenzofuranylimidazoline compound 7 is the only analogue possessing presynaptic antagonist potency potency and selectivity comparable to that of 1. In view of this result, a number of derivatives was prepared to determine the structure-activity relationships within this series. Many derivatives, as well as the parent compound 7, were found to possess presynaptic alpha 2-adrenoreceptor antagonist and postsynaptic alpha 1-adrenoreceptor partial agonist properties. Two of the selective presynaptic antagonists, 13 and 14 possess greater potency and selectivity than that possessed by 1. The 5-chloro derivative 25 is twice as potent as after oral administration but only about half as potent when given intravenously.
Subject(s)
Adrenergic alpha-Antagonists/chemical synthesis , Dioxanes/chemical synthesis , Dioxanes/pharmacology , Dioxins/chemical synthesis , Dioxins/pharmacology , Receptors, Adrenergic, alpha/drug effects , Animals , Idazoxan , Indicators and Reagents , Male , Mice , Muscles/drug effects , Phenylephrine/pharmacology , Rats , Rats, Inbred Strains , Structure-Activity Relationship , Synapses/drug effects , Vas Deferens/drug effectsABSTRACT
A case report is presented in which abruptio placenta occurs five days after trauma. This is a very rare occurrence. The high incidence of abruption occurring after severe trauma is reviewed, and the importance of continuous fetal monitoring for at least 48 hours after admission to the hospital is stressed.
