ABSTRACT
Purpose: The present study aimed to examine the association between the stage of pelvic organ prolapse (POP) and the risk of fracture in postmenopausal women.Methods: A cross-sectional design was used, which included 133 women with POP over 50 years of age. The participants were classified according to their POP stage, underwent blood tests (hemogram, biochemistry, bone remodeling markers, and hormone tests), and completed a sociodemographic and lifestyle questionnaire along with densitometry, FRAX, and FRIDEX tests.Results: Of the 133 women studied, 66 presented stages I-II POP (49.6%) and 67 III-IV POP (50.4%). The mean age of the participants was 64.47 years. Women with a high POP stage showed higher FRAX scores for major osteoporotic and hip fracture (p .001 and p < .001p). Bivariate analysis revealed that higher scores on the FRIDEX scale were associated with a higher POP stage (p = .032). In addition, there was a marginally significant negative association between bone mineral density (BMD) and POP stage (p = .054).Conclusions: High-stage POP can be considered an independent predictor of osteoporotic fracture risk, as measured using the FRAX and FRIDEX scales.
Subject(s)
Osteoporotic Fractures , Pelvic Organ Prolapse , Female , Humans , Middle Aged , Cross-Sectional Studies , Risk Factors , Bone Density , Pelvic Organ Prolapse/complications , Risk AssessmentABSTRACT
BACKGROUND AND OBJETIVE: On January 7th, 2020, a new coronavirus, SARS-CoV-2, was identified, as responsible for a new human disease: COVID-19. Given its recent appearance, our current knowledge about the possible influence that this disease can exert on pregnancy is very limited. One of the unknowns to be solved is whether there is a vertical transmission of the infection during pregnancy. PATIENTS AND METHODS: Using the Real-time Polymerase Chain Reaction techniques for SARS-CoV-2 nucleic acids, the possible presence of this germ in vaginal discharge and amniotic fluid was investigated in four pregnant Caucasian patients affected by mild acute symptoms of COVID-19 during the second trimester of pregnancy. RESULTS: There is no laboratory evidence to suggest a possible passage of SARS-CoV-2 from the infected mother to the amniotic fluid. CONCLUSIONS: It is necessary to expand the investigation of COVID-19 cases diagnosed during pregnancy to clarify the real influence that SARS-CoV-2 has on pregnant women and their offspring, as well as those factors that modulate the disease.
Subject(s)
COVID-19/transmission , Infectious Disease Transmission, Vertical , Pregnancy Complications, Infectious , Adult , Amniotic Fluid/virology , COVID-19/diagnosis , COVID-19 Nucleic Acid Testing , Female , Humans , Pregnancy , Pregnancy Complications, Infectious/diagnosis , Pregnancy Trimester, Second , Vaginal Discharge/virologyABSTRACT
Antecedentes y objetivo El 07 de enero de 2020 se identificó un nuevo coronavirus, el SARS-CoV-2, responsable de una nueva enfermedad en el humano: la COVID-19. Dada su reciente aparición, nuestro conocimiento actual sobre la posible influencia que esta enfermedad puede ejercer en el embarazo es muy limitado. Una de las incógnitas que hay que despejar es si existe transmisión vertical de la infección durante la gestación. Pacientes y métodos Mediante técnicas de reacción en cadena de la polimerasa en tiempo real para ácidos nucleicos del SARS-CoV-2 se investigó la posible presencia de dicho germen en el flujo vaginal y el líquido amniótico de cuatro pacientes embarazadas de raza caucásica afectadas por cuadros agudos leves de COVID-19 durante el segundo trimestre de la gestación. Resultados No existen evidencias de laboratorio que sugieran un posible paso del SARS-CoV-2 desde la madre infectada al líquido amniótico. Conclusiones Es preciso ampliar la investigación de casos de COVID-19 diagnosticados durante la gestación para poder aclarar la influencia real que el SARS-CoV-2 ejerce sobre las embarazadas y su descendencia, así como aquellos factores que modulan la enfermedad (AU)
Background and objective On January 7th, 2020, a new coronavirus, SARS-CoV-2, was identified, as responsible for a new human disease: COVID-19. Given its recent appearance, our current knowledge about the possible influence that this disease can exert on pregnancy is very limited. One of the unknowns to be solved is whether there is a vertical transmission of the infection during pregnancy. Patients and methods Using the Real-time Polymerase Chain Reaction techniques for SARS-CoV-2 nucleic acids, the possible presence of this germ in vaginal discharge and amniotic fluid was investigated in four pregnant Caucasian patients affected by mild acute symptoms of COVID-19 during the second trimester of pregnancy. Results There is no laboratory evidence to suggest a possible passage of SARS-CoV-2 from the infected mother to the amniotic fluid. Conclusions It is necessary to expand the investigation of COVID-19 cases diagnosed during pregnancy to clarify the real influence that SARS-CoV-2 has on pregnant women and their offspring, as well as those factors that modulate the disease (AU)
Subject(s)
Humans , Female , Pregnancy , Adult , Infectious Disease Transmission, Vertical , Pregnancy Complications, Infectious/virology , Coronavirus Infections/transmissionABSTRACT
BACKGROUND AND OBJECTIVE: On January 7th, 2020, a new coronavirus, SARS-CoV-2, was identified, as responsible for a new human disease: COVID-19. Given its recent appearance, our current knowledge about the possible influence that this disease can exert on pregnancy is very limited. One of the unknowns to be solved is whether there is a vertical transmission of the infection during pregnancy. PATIENTS AND METHODS: Using the Real-time Polymerase Chain Reaction techniques for SARS-CoV-2 nucleic acids, the possible presence of this germ in vaginal discharge and amniotic fluid was investigated in four pregnant Caucasian patients affected by mild acute symptoms of COVID-19 during the second trimester of pregnancy. RESULTS: There is no laboratory evidence to suggest a possible passage of SARS-CoV-2 from the infected mother to the amniotic fluid. CONCLUSIONS: It is necessary to expand the investigation of COVID-19 cases diagnosed during pregnancy to clarify the real influence that SARS-CoV-2 has on pregnant women and their offspring, as well as those factors that modulate the disease.
