ABSTRACT
Two boys aged 13 and 7 years, displayed chronic coughing, dyspnoea on exertion, anorexia, weight loss, and fatigue. At first a diagnosis of asthma was made. However, a correct interpretation of anamnestic and clinical features, laboratory findings and radiographic results led to the diagnosis of 'pigeon breeder's disease' in both cases. Both patients recovered after drug treatment and avoidance of re-exposure to pigeon antigen.
Subject(s)
Asthma/diagnosis , Bird Fancier's Lung/diagnosis , Adolescent , Alveolitis, Extrinsic Allergic/diagnosis , Animals , Anti-Inflammatory Agents/therapeutic use , Bird Fancier's Lung/drug therapy , Bird Fancier's Lung/etiology , Bird Fancier's Lung/immunology , Child , Columbidae , Diagnosis, Differential , Humans , Immunoglobulin G , Lung/diagnostic imaging , Lung/immunology , Male , Prednisone/therapeutic use , Radiography , Respiratory Function Tests , Treatment OutcomeABSTRACT
We report five new patients with coeliac disease and Down syndrome and review the 11 cases previously reported in the literature. In 14 of these 16 patients diarrhoea was the presenting symptom and in 2 failure to thrive in combination with anaemia. The frequency of coeliac disease in children with Down syndrome was calculated as being 43 times greater than in children without Down syndrome. Delay between first symptoms and diagnosis in patients with combined coeliac disease and Down syndrome was 2.5 years, while in the other children with coeliac disease it was only 8 months. This distinctive difference could be caused by an underestimation of the seriousness of gastro-intestinal complaints in patients with Down syndrome. It is stressed that coeliac disease should be strongly considered in all children with Down syndrome and either persistent diarrhoea or failure to thrive.
