Deconstructing the functional significance of the error-related negativity (ERN) and midline frontal theta oscillations using stepwise time-locking and single-trial response dynamics.

Error-related electroencephalographic potentials have been used for decades to develop theoretical models of response monitoring processes, study altered cognitive functioning in clinical populations, and more recently, to improve the performance of brain-computer interfaces. However, the vast majority of this research relies on discrete behavioral responses that confound error detection, response cancelation, error correction, and post-error cognitive and affective processes. By contrast, the present study demonstrates a novel, complementary method for isolating the functional correlates of error-related electroencephalographic responses using single-trial kinematic analyses of cursor trajectories and a stepwise time-locking analysis. The results reveal that the latency of the ERN, Pe, and medial-frontal theta oscillations are all strongly positively correlated with the latency at which an initiated error response is canceled, as indicated by the peak deceleration of the initiated movement prior to a corrective response. Results are discussed with respect to current theoretical models of error-related brain potentials and potential relevance to clinical applications.

Perceived need for care and mental health service utilization among college students with suicidal ideation.

OBJECTIVE: This study aimed to identify correlates of service utilization and perceived need for care among college students with suicidal ideation. PARTICIPANTS: Respondents were recruited from introductory psychology courses at an undergraduate college during the Fall 2014 semester. METHODS: Independent correlates of (1) mental health service utilization, (2) self-perceived need, and (3) other-perceived need for mental health services among college students (N = 190) with suicidal ideation were identified. RESULTS: Service utilization was associated with need for care as perceived by others. Perceived need for care by others was associated with suicidal ideation intensity and suicide attempt history. Perceived need by the respondents themselves was correlated with depression severity, sex, and race but was not independently associated with actual service utilization. CONCLUSIONS: Perceived need by others was the sole significant correlate of service utilization, suggesting it is an important target for public health interventions aimed at facilitating pathways into mental health treatment.

Investigating the association between emotion regulation and distress in adults with psychotic-like experiences.

Many individuals in the general population experience psychotic-like experiences in the absence of a psychotic disorder. The degree of psychological distress associated with these experiences is a key predictor of clinical outcomes. One factor that may influence the degree of distress from psychotic-like experiences is emotion regulation. Although it has been demonstrated that emotion regulation deficits are present in psychotic disorders, the association between emotion regulation and subclinical psychotic-like experiences is not well understood. Here, we examined the associations between frequency of and distress from psychotic-like experiences and several key components of emotion regulation: difficulties with emotion regulation; emotion regulation self-efficacy; and emotion regulation strategy use. Difficulties with emotion regulation and maladaptive patterns of emotion regulation strategy use were associated with the frequency of both positive and negative psychotic-like experiences. In addition, results suggest that habitual acceptance use and reappraisal self-efficacy may serve as protective factors against the distress associated with psychotic-like experiences.

Social information influences emotional experience and late positive potential response to affective pictures.

Emotion experience and regulation frequently occur in social settings. Social influence is a common source of unconscious change in judgment in many contexts, but it has yet to be investigated as a form of automatic emotion regulation. Here, we demonstrate that nonpredictive social information (i.e., high or low "emotion intensity ratings from other people" that were not related to the actual intensity of the pictures) about the intensity of pleasant and unpleasant picture stimuli can influence self-reported emotional experience and the magnitude of the late positive potential, an event-related potential associated with the detection of emotional salience and sustained attention to motivationally significant stimulus features. These results show that emotional responses to pleasant and unpleasant affective pictures can be altered by nonpredictive social information on both the behavioral and the neurophysiological level. (PsycINFO Database Record

Screening for sub-threshold psychotic experiences and perceived need for psychological services.

AIM: Sub-threshold psychotic experiences (PEs) are common in the general population and may increase risk for psychological distress and psychosis onset, generating a need for effective community screening instruments. This study aimed to explore the utility of a brief, self-report, psychosis risk screening tool in predicting perceived need for psychological treatment among a non-clinical sample, above and beyond that accounted for by accompanying forms of psychopathology or trait neuroticism. METHODS: Construct validity, predictive validity and test-retest reliability of the brief, self-report questionnaire for screening putative prepsychotic states were determined among college students (N = 679). Multiple linear regression analyses were conducted to explore the relationship between PEs and perceived need for psychological services. RESULTS: With the exception of auditory perceptual disturbances, PEs were not significantly associated with one's need for services, or the belief from others that services are needed, after controlling for neuroticism, anxiety and depressive symptoms. Auditory perceptual disturbances were significantly associated with the perceived need for psychological services, even after accounting for these additional symptoms. CONCLUSIONS: These results confirm the usefulness of the psychosis risk screening tool in evaluating the presence of sub-threshold PEs, particularly auditory perceptual disturbances. The relationship between other PEs and a perceived need for psychological services, however, was largely explained by the existence of neurotic traits and anxiety and depressive symptoms. Screening for auditory perceptual disturbances may be useful in identifying unmet clinical need among young adults.

Psychotic experiences in the context of depression: The cumulative role of victimization.

Previous studies have reported an association between depression and psychotic experiences, but little is known about what drives this co-occurrence. This study tests the hypothesis that exposure to trauma and bullying may strengthen the relation between depression and psychotic experiences. A total of 799 college students completed self-report questionnaires on psychotic experiences, depression, bullying, and sexual trauma. Hierarchical linear regression analyses were conducted to test the direct relationship between depression and psychotic experiences, as well as interactions. Approximately 20% of respondents reported a history of being bullied, and 7% reported exposure to childhood sexual trauma. There was a significant direct relationship between depression and psychotic experiences. The association between depression and psychotic experiences was significantly stronger among respondents who were victims of both bullying and sexual violence compared to those who experienced either exposure alone, or who were not exposed to either form of victimization. These findings suggest that cumulative exposure to trauma and victimization may contribute to the co-occurrence of depression and psychotic experiences. History of victimization should be assessed among individuals with depressive symptoms to improve treatment plans and outcomes.

Investigating the Relationship Between Self-Esteem and Stigma Among Young Adults With History of Suicide Attempts.

BACKGROUND: Self-esteem is a major contributor to risk for repeated suicide attempts. Prior research has shown that awareness of stigma is associated with reduced self-esteem among people with mental illness. No prior studies have examined the association between self-esteem and stereotype awareness among individuals with past suicide attempts. AIMS: To understand the relationship between stereotype awareness and self-esteem among young adults who have and have not attempted suicide. METHOD: Computerized surveys were administered to college students (N = 637). Linear regression analyses were used to test associations between self-esteem and stereotype awareness, attempt history, and their interaction. RESULTS: There was a significant stereotype awareness by attempt interaction (ß = -.74, p = .006) in the regression analysis. The interaction was explained by a stronger negative association between stereotype awareness and self-esteem among individuals with past suicide attempts (ß = -.50, p = .013) compared with those without attempts (ß = -.09, p = .037). CONCLUSION: Stigma is associated with lower self-esteem within this high-functioning sample of young adults with histories of suicide attempts. Alleviating the impact of stigma at the individual (clinical) or community (public health) levels may improve self-esteem among this high-risk population, which could potentially influence subsequent suicide risk.

Explanatory risk factors in the relations between schizotypy and indicators of suicide risk.

Schizotypy has been linked to suicide risk, but it is not known whether established suicide-related risk factors mediate this relation. The aim of this study was to assess the mediating effects of depressive symptoms, social anxiety, self-esteem, and intimate disclosure in peer relationships in the relation between interpersonal schizotypy and suicide ideation or lifetime suicide attempts. This aim was tested in 590 young adults using a nonparametric bootstrapping procedure. After inclusion of the mediators, interpersonal schizotypy was no longer directly associated with either suicide ideation or lifetime suicide attempts. Depression and self-esteem mediated the relation between interpersonal schizotypy and suicide ideation. No variables mediated the relation between interpersonal schizotypy and lifetime suicide attempts, and there were no significant direct relations when mediators were included. Schizotypy appears to be a distal risk factor for suicidal behavior; assessing depressive symptoms and self-esteem may provide more proximal information about suicide risk, and may be targets for mitigating suicide risk in individuals with schizotypy.

Differential effects of self- and situation-focused reappraisal.

In the present research, we investigated the effects of self- and situation-focused reappraisal, which are 2 distinct types of cognitive reappraisal, on emotion experiences, memory, and electrocortical responses to unpleasant pictures. In Study 1, situation-focused reappraisal was found to improve recall accuracy, whereas self-focused reappraisal had no effect. Both strategy types were associated with reductions in self-reported negative emotion, with larger reductions during situation-focused reappraisal. In Study 2, event-related potentials (ERPs) were measured while participants engaged in the 2 strategy types. Situation-focused, but not self-focused, reappraisal was associated with reductions in the late positive potential, an ERP that reflects facilitated attention to emotional stimuli. Taken together, these findings suggest that reappraisal is not a homogenous regulation strategy; on the contrary, subtypes of reappraisal elicit distinct consequence profiles. (PsycINFO Database Record

Social and psychological contributions to the co-occurrence of sub-threshold psychotic experiences and suicidal behavior.

PURPOSE: Psychotic experiences and suicidal behavior commonly co-occur in the general population, which can have implications for suicide prevention approaches. However, little is known about the nature of this relation in non-clinical samples. This cross-sectional study aimed to address a research gap by testing whether the relation between psychotic experiences and suicide-related outcomes (ideation, intent, and attempts) is explained by common social and psychological factors. METHODS: Young adult college students (N = 590) were assessed for psychotic experiences, suicidal behavior, and a comprehensive set of 24 potential shared risk factors selected through review of past epidemiological studies and meta-analyses. Nonparametric bootstrapped regression models were used to examine whether these factors attenuated or eliminated the associations between psychotic experiences and suicide-related outcomes. RESULTS: Psychotic experiences were associated with greater risk for suicidal ideation and behaviors. Adjustment for psychosocial factors, particularly those contributing to cumulative stress, accounted for the associations between psychotic experiences and suicide-related outcomes, except broadly defined suicidal ideation. CONCLUSIONS: These results suggest that the robust associations between psychotic experiences and suicidal behavior demonstrated in past studies may be primarily explained by shared risk factors, rather than by causal relations. In our sample, suicidal behavior and sub-threshold psychosis appear to be trans diagnostic clinical outcomes that share common causes, notably cumulative stress, but do not cause one another.

Suicide Risk, Stress Sensitivity, and Self-Esteem among Young Adults Reporting Auditory Hallucinations.

Individuals with subthreshold psychotic experiences are at increased risk for suicidal thoughts and behavior, similar to those with schizophrenia and other psychotic disorders. This may be explained by shared risk factors such as heightened stress sensitivity or low self-esteem. Understanding the nature of this relationship could inform suicide prevention in social work practice. In this study, authors examined the relationship between self-reported auditory hallucinations and suicidal thoughts, plans, and attempts, in a nonclinical sample of young adults, controlling for scores on the Psychological Stress Index and Rosenberg Self-Esteem Scale. Auditory hallucinations were associated with approximately double the odds of suicidal ideation and plans and four times the odds for suicide attempts. This relationship was not explained by stress sensitivity or self-esteem, which were independently related to hallucinations and suicidality, respectively. Subthreshold auditory hallucinations may be a useful indicator of suicide risk. This association may represent a clinically significant relationship that may be addressed through social work interventions intended to alleviate stress sensitivity or improve self-esteem.

Fermented foods, neuroticism, and social anxiety: An interaction model.

Animal models and clinical trials in humans suggest that probiotics can have an anxiolytic effect. However, no studies have examined the relationship between probiotics and social anxiety. Here we employ a cross-sectional approach to determine whether consumption of fermented foods likely to contain probiotics interacts with neuroticism to predict social anxiety symptoms. A sample of young adults (N=710, 445 female) completed self-report measures of fermented food consumption, neuroticism, and social anxiety. An interaction model, controlling for demographics, general consumption of healthful foods, and exercise frequency, showed that exercise frequency, neuroticism, and fermented food consumption significantly and independently predicted social anxiety. Moreover, fermented food consumption also interacted with neuroticism in predicting social anxiety. Specifically, for those high in neuroticism, higher frequency of fermented food consumption was associated with fewer symptoms of social anxiety. Taken together with previous studies, the results suggest that fermented foods that contain probiotics may have a protective effect against social anxiety symptoms for those at higher genetic risk, as indexed by trait neuroticism. While additional research is necessary to determine the direction of causality, these results suggest that consumption of fermented foods that contain probiotics may serve as a low-risk intervention for reducing social anxiety.

Effects of subcallosal cingulate deep brain stimulation on negative self-bias in patients with treatment-resistant depression.

BACKGROUND: The cognitive neuropsychological model states that antidepressant treatment alters emotional biases early in treatment, and after this initial change in emotional processing, environmental and social interactions allow for long-term/sustained changes in mood and behavior. OBJECTIVE: Changes in negative self-bias after chronic subcallosal cingulate (SCC) deep brain stimulation (DBS) were investigated with the hypothesis that treatment would lead to changes in emotional biases followed by changes in symptom severity. METHODS: Patients (N = 7) with treatment-resistant depression were assessed at three time points: pre-treatment; after one month stimulation; and after six months stimulation. The P1, P2, P3, and LPP (late positive potential) components of the event-related potential elicited by positive and negative trait adjectives were recorded in both a self-referential task and a general emotion recognition task. RESULTS: Results indicate that DBS reduced automatic attentional bias toward negative words early in treatment, as indexed by the P1 component, and controlled processing of negative words later in treatment, as indexed by the P3 component. Reduction in negative words endorsed as self-descriptive after six months DBS was associated with reduced depression severity after six months DBS. Change in emotional processing may be restricted to the self-referential task. CONCLUSIONS: Together, these results suggest that the cognitive neuropsychological model, developed to explain the time-course of monoamine antidepressant treatment, may also be used as a framework to interpret the antidepressant effects of SCC DBS.

Screening for psychotic experiences: social desirability biases in a non-clinical sample.

AIM: Subthreshold psychotic experiences are common in the population and may be clinically significant. Reporting of psychotic experiences through self-report screens may be subject to threats to validity, including social desirability biases. This study examines the influence of social desirability on the reporting of psychotic experiences. METHODS: College students (n = 686) completed a psychosis screen and the Marlowe-Crowne social desirability scale as part of a self-report survey battery. Associations between psychosis and social desirability were tested using logistic regression models. RESULTS: With the exception of auditory hallucinations, all other measures of psychotic experiences were subject to social desirability biases. Respondents who gave more socially desirable answers were less likely to report psychotic experiences. CONCLUSIONS: Respondent's tendency to underreport psychotic experiences should be accounted for when screening for these symptoms clinically. Findings also suggest that population figures based on self-report may underestimate the prevalence of subthreshold delusions but not hallucinations.

Age-related differences in event-related potentials for early visual processing of emotional faces.

With advancing age, processing resources are shifted away from negative emotional stimuli and toward positive ones. Here, we explored this 'positivity effect' using event-related potentials (ERPs). Participants identified the presence or absence of a visual probe that appeared over photographs of emotional faces. The ERPs elicited by the onsets of angry, sad, happy and neutral faces were recorded. We examined the frontocentral emotional positivity (FcEP), which is defined as a positive deflection in the waveforms elicited by emotional expressions relative to neutral faces early on in the time course of the ERP. The FcEP is thought to reflect enhanced early processing of emotional expressions. The results show that within the first 130 ms young adults show an FcEP to negative emotional expressions, whereas older adults show an FcEP to positive emotional expressions. These findings provide additional evidence that the age-related positivity effect in emotion processing can be traced to automatic processes that are evident very early in the processing of emotional facial expressions.

Event-related potentials reveal the effect of prior knowledge on competition for representation and attentional capture.

Objects compete for representation in our limited capacity visual system. We examined how this competition is influenced by top-down knowledge using event-related potentials. Competition was manipulated by presenting visual search arrays in which the target or distractor was the only color singleton compared to displays in which both singletons were presented. Experiments 1 and 2 manipulated whether the observer knew the color of the target in advance. Experiment 3 ruled out low-level sensory explanations. Results show that, under conditions of competition, the distractor does not elicit an N2pc when the target color is known. However, the N2pc elicited by the target is reduced in the presence of a distractor. These findings suggest that top-down knowledge can prevent the capture of attention by distracting information, but this prior knowledge does not eliminate the competitive influence of the distractor on the target.

Frontal theta cordance predicts 6-month antidepressant response to subcallosal cingulate deep brain stimulation for treatment-resistant depression: a pilot study.

Deep brain stimulation (DBS) of subcallosal cingulate white matter (SCC) may be an effective approach for treatment-resistant depression (TRD) that otherwise fails to respond to more conventional therapies, but DBS is invasive, costly, and has potential for adverse effects. Therefore, it is important to identify potential biomarkers for predicting antidepressant response before intervention. Resting-state EEG was recorded from 12 TRD patients at pre-treatment baseline, after 4 weeks SCC DBS, and after 24 weeks SCC DBS. Lower frontal theta cordance (FTC) at baseline (and higher FTC after 4 weeks) predicted lower depression severity scores after 24 weeks. Greater FTC increases (baseline-4 weeks) predicted greater decreases in depression severity scores subsequently (4-24 weeks) and over the course of the study (baseline-24 weeks). Predictive relationships were topographically specific to theta cordance for frontal electrodes. Thus, results from this pilot study suggest that baseline FTC and changes early in treatment each have utility as biomarkers for predicting 6-month clinical response to SCC DBS for TRD.

Target resolution in visual search involves the direct suppression of distractors: evidence from electrophysiology.

Attentional selection requires both the enhancement of target stimuli and the suppression of distractors. Target enhancement and distractor suppression have been associated with separable components of the lateralized event-related potential: the target negativity and distractor positivity (Pd). We examined the distractor suppression mechanisms indexed by the Pd. The Pd may reflect mechanisms that guide attention away from distractors during search or mechanisms involved in the subsequent resolution of target features. To determine which of these alternatives was more likely, we had participants view search arrays that contained only a target, only a distractor, or both. The Pd elicited by distractors was substantially larger when the display also contained a target, consistent with the idea that this component reflects a mechanism of distractor suppression activated during the resolution and disambiguation of target features.

Orienting to external versus internal regions of space: consequences of attending in advance versus after the fact.

We examined effects of knowing where to attend to-be-remembered information in advance versus after the fact. Participants performed a visuospatial short-term memory task with orienting cues that appeared before or after a memory display and reported whether a probe item had appeared on the cued side. Event-related potentials (ERPs) were recorded for cues, memory displays, and probes. Performance was better in precued versus postcued conditions. ERPs to orienting cues and memory displays were lateralized in relation to the direction of attention in precued but not postcued conditions. ERPs to recognition probes were lateralized, but this was similar between pre- and postcued conditions. Results suggest that we can orient visuospatial attention outwardly to external events and inwardly to remembered events alike, but knowing where to attend information in advance gives a bigger boost to brain and behavior.

Dynamics of target and distractor processing in visual search: evidence from event-related brain potentials.

When multiple objects are present in a visual scene, salient and behaviorally relevant objects are attentionally selected and receive enhanced processing at the expense of less salient or less relevant objects. Here we examined three lateralized components of the event-related potential (ERP) - the N2pc, Ptc, and SPCN - as indices of target and distractor processing in a visual search paradigm. Participants responded to the orientation of a target while ignoring an attentionally salient distractor and ERPs elicited by the target and the distractor were obtained. Results indicate that both the target and the distractor elicit an N2pc component which may index the initial attentional selection of both objects. In contrast, only the distractor elicited a significant Ptc, which may reflect the subsequent suppression of distracting or irrelevant information. Thus, the Ptc component appears to be similar to another ERP component - the Pd - which is also thought to reflect distractor suppression. Furthermore, only the target elicited an SPCN component which likely reflects the representation of the target in visual short term memory.