ABSTRACT
Further investigation of the chemistry of the eleven-membered cyclic sesquiterpene, zerumbone, the major component of the wild ginger, Zingiber zerumbet Smith, has revealed a new selective epoxidation process, a further example of a novel Favorskii-initiated double ring contraction, and a regiospecific fragmentation of zerumbone dibromide derivatives. Several zerumbone derivatives were found to be selective inhibitors of the growth of gram-positive bacteria.
Subject(s)
Anti-Bacterial Agents/chemistry , Anti-Bacterial Agents/pharmacology , Protein Kinases , Sesquiterpenes/chemistry , Sesquiterpenes/pharmacology , Asarum/chemistry , Bacillus subtilis/drug effects , Bacillus subtilis/metabolism , Crystallography, X-Ray , Escherichia coli/drug effects , Escherichia coli/metabolism , Histidine Kinase , Microbial Sensitivity Tests , Molecular Structure , Protein Kinase InhibitorsABSTRACT
Assessing the value of your practice requires careful planning. This article discusses the reasons, methods and pitfalls of practice valuation.
Subject(s)
Practice Management, Dental/economics , Commerce , Costs and Cost Analysis , Humans , Income , Ownership , Partnership Practice, Dental/economicsABSTRACT
A pedicle skin flap based on the caudal superficial epigastric artery was created in 12 cats. The artery was ligated and the vein left intact. Six cats were treated with hyperbaric oxygen at 2 atm absolute for 90 minutes daily for 14 days, starting the day after surgery. Skin flap color was significantly better in the treated cats on days 1, 2, and 3. The amount of exudate was significantly less in the treated cats on day 3. There was no difference in the amount of swelling between treated and nontreated control cats. Although five of six of the treated cats had 100% skin flap survival, there was no significant difference in total flap survival between treated and nontreated control cats.
Subject(s)
Cats/surgery , Dermatologic Surgical Procedures , Hyperbaric Oxygenation/veterinary , Surgical Flaps/veterinary , Wound Healing , Abdominal Muscles/blood supply , Animals , Skin/pathologySubject(s)
Practice Management, Dental/economics , Retirement/economics , Commerce , Humans , OwnershipSubject(s)
Hyperbaric Oxygenation , Oxygen Inhalation Therapy , Humans , Oxygen/blood , Partial PressureABSTRACT
(2RS,3S,4S)-[2-14C,4-3H]Isoleucine and (2S,3S,4R)-[U-14C,4-3H]isoleucine have been prepared by stereospecific syntheses. The addition of these substrates to Streptomyces cacaoi led to the isolation of polyoxins from which 3-ethylidene-L-azetidine-2-carboxylic acid was isolated by hydrolysis. The pro-R hydrogen at C-4 of isoleucine was lost and the pro-S hydrogen was retained in the biosynthesis of 3-ethylidene-L-azetidine-2-carboxylic acid. These results indicate that the enzymatic dehydrogenation of isoleucine to form 3-ethylidene-L-azetidine-2-carboxylic acid involves the antiperiplanar elimination of the hydrogen at C-3 and the pro-R hydrogen at C-4.
Subject(s)
Isoleucine/metabolism , Streptomyces/metabolism , Azetidinecarboxylic Acid/analogs & derivatives , Azetidinecarboxylic Acid/biosynthesis , Carbon Radioisotopes , Radioisotope Dilution Technique , Stereoisomerism , TritiumABSTRACT
Many of the methods for evaluating the quality of ambulatory care are costly, cumbersome, and possibly counterproductive. Major developments in evaluating the quality of the doctor-patient relationship are needed before a general assessment of the quality of ambulatory care is possible. Nonetheless, limited reviews based on insurance claims data can efficiently improve certain aspects of ambulatory care.
