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Boronic acid liposomes for cellular delivery and content release driven by carbohydrate binding.

Zhang, Xiaoyu; Alves, Daiane S; Lou, Jinchao; Hill, Shelby D; Barrera, Francisco N; Best, Michael D.

Chem Commun (Camb) ; 54(48): 6169-6172, 2018 Jun 12.

Article in English | MEDLINE | ID: mdl-29809225

ABSTRACT

Boronic acid liposomes enable triggered content release and cell delivery driven by carbohydrate binding. Dye release assays using hydrophilic and hydrophobic fluorophores validate dose-dependent release upon carbohydrate treatment. Microscopy results indicate dramatic enhancements in cell delivery, showcasing the prospects of boronic acid lipids for drug delivery.

Subject(s)

Boronic Acids/chemistry , Diglycerides/chemistry , Drug Carriers/chemistry , Heparin/chemistry , Unilamellar Liposomes/chemistry , Boronic Acids/chemical synthesis , Boronic Acids/metabolism , Boronic Acids/toxicity , Cell Line, Tumor , Diglycerides/chemical synthesis , Diglycerides/metabolism , Diglycerides/toxicity , Drug Carriers/chemical synthesis , Drug Carriers/metabolism , Drug Carriers/toxicity , Drug Liberation , Fluorescent Dyes/chemistry , Humans , Oxazines/chemistry , Pinocytosis/drug effects , Rhodamines/chemistry , Unilamellar Liposomes/chemical synthesis , Unilamellar Liposomes/metabolism , Unilamellar Liposomes/toxicity

ABSTRACT

Subject(s)

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