ABSTRACT
ABSTRACT: A 66-year-old man was referred for a 68Ga-prostate-specific membrane antigen (PSMA) PET/CT scan for primary staging of Gleason 8 prostatic adenocarcinoma. The PET/CT images confirmed PSMA activity in the bilateral prostatic apex in keeping with the known malignancy. An intensely PSMA-avid focus was also noted in a nonenlarged right femoral lymph node with no evidence of PSMA-avid metastatic disease elsewhere. Subsequent core biopsy and histopathology confirmed a solitary metastatic focus of prostatic adenocarcinoma in a right femoral lymph node.
Subject(s)
Adenocarcinoma/pathology , Edetic Acid/analogs & derivatives , Oligopeptides , Positron Emission Tomography Computed Tomography , Prostatic Neoplasms/pathology , Aged , Biopsy, Large-Core Needle , Gallium Isotopes , Gallium Radioisotopes , Humans , Lymphatic Metastasis , MaleABSTRACT
A 76-year-old man with previously treated prostatic adenocarcinoma (Gleason 8) was referred for a Ga-prostate-specific membrane antigen PET/CT scan due to a rising serum PSA level. An intensely PSMA-avid focus was demonstrated in the left proximal tibia with no evidence of local recurrence or metastatic disease elsewhere. This was diagnosed and managed as enthesopathy. A Tc-MDP bone scan with SPECT/CT performed 9 months later confirmed an intensely osteoblastic mixed lytic/sclerotic metastasis at the left proximal tibia.
Subject(s)
Adenocarcinoma/pathology , Bone Neoplasms/diagnostic imaging , Bone Neoplasms/secondary , Enthesopathy/diagnostic imaging , Membrane Glycoproteins , Organometallic Compounds , Prostatic Neoplasms/pathology , Tibia/pathology , Aged , Diagnosis, Differential , Gallium Isotopes , Gallium Radioisotopes , Humans , Male , Positron Emission Tomography Computed Tomography , Tibia/diagnostic imagingABSTRACT
A 74-year-old man with prostate adenocarcinoma (Gleason 7) was referred for Ga-prostate-specific membrane antigen (PSMA-HBED-CC) PET/CT scan for staging. Findings confirmed the prostate malignancy and demonstrated a solitary metastasis in the left skull base, with no evidence of regional or distant metastasis elsewhere. Solitary base of the skull metastasis may be subtle and easily overlooked, highlighting the need for thorough evaluation of the region.
