1.
Res Commun Chem Pathol Pharmacol
; 22(3): 573-80, 1978 Dec.
Article
in English
| MEDLINE
| ID: mdl-734235
ABSTRACT
Ethanol or 1,3-butanediol ingestion during pregnancy and lactation results in a marked inhibition of neuronal protein synthesis in the 18-day-old rat progeny, however the same treatment had a stimulatory effect on the amino acid incorporation by neuronal perikarya of 8-day-old pups. Liver protein synthesis in vitro, on the other hand, was enhanced in both 8-day and 18-day-old pups as a consequence of maternal ethanol consumption. This was attributable to increased amino-acylation in the liver pH 5 enzyme fraction.
Subject(s)
Butylene Glycols/pharmacology , Ethanol/pharmacology , Liver/metabolism , Nerve Tissue Proteins/biosynthesis , Neurons/metabolism , Protein Biosynthesis , Aging , Amino Acids/metabolism , Animals , Female , Liver/drug effects , Maternal-Fetal Exchange , Neurons/drug effects , Pregnancy , RNA/biosynthesis , Rats , Ribosomes/metabolism
2.
J Chronic Dis
; 28(5-6): 259-87, 1975 Jun.
Article
in English
| MEDLINE
| ID: mdl-1141423