Subject(s)
Diagnosis-Related Groups , National Health Programs , Wounds and Injuries/surgery , Adult , Aged , Ankle Injuries/classification , Ankle Injuries/surgery , Documentation/methods , Female , Fractures, Bone/classification , Fractures, Bone/surgery , Germany , Humans , Male , Middle Aged , Multiple Trauma/classification , Multiple Trauma/surgery , Radius Fractures/classification , Radius Fractures/surgery , Scapula/injuries , Scapula/surgery , Sprains and Strains/classification , Sprains and Strains/surgery , Wounds and Injuries/classification , Wrist Injuries/classification , Wrist Injuries/surgeryABSTRACT
1. Single, very low dose of gold (500 micrograms/kg body weight) was given intramuscularly to male Sprague-Dawley rats (mean body weight: 200 g) as aurothiokeratinate (Auro-Detoxin(R) dissolved in 0.9% NaCl. 2. Blood, liver and kidney were samples at autopsy 0.5, 1, 2, 3, 6 and 12 h after the gold injection (six animals per time). 12 rats were treated with 0.9% saline only as controls. The zinc (Zn), copper (Cu), gold and metallothionein (MT) concentrations were determined in homogenates and cytosols of liver and kidney using atomic absorption spectrometry and gel chromatography, respectively. 3. The main changes in metal and MT concentrations occurred in the kidney, where an increase of gold was found 0.5 h after the injection, followed by an increase in Cu and MT concentrations after 6 h. Zn homeostasis did not change. 4. The results suggest that gold by itself induces an increase of MT-like peptides in the kidney cytosol, which was accompanied by an increase in the concentration of Cu mainly bound to these MT-like peptides.
Subject(s)
Copper/metabolism , Gold/pharmacology , Kidney/drug effects , Liver/drug effects , Metallothionein/metabolism , Zinc/metabolism , Animals , Kidney/metabolism , Liver/metabolism , Male , Rats , Time FactorsABSTRACT
A four-year-old boy had been complaining for one year of backache when sitting or bending. Radiological changes in the lumbar spine were at first interpreted as due to an old vertebral fracture. Half a year after the onset of the symptoms his sister was found to have open pulmonary tuberculosis, but a positive Tine test (he had not received BCG vaccination) was without any consequences. He was finally hospitalized five months later because the backache persisted and he now also had impaired movement of the left hip-joint. Physical examination revealed a 10 x 15 cm firm mass in the abdomen. Imaging demonstrated destruction of the 4th and 5th lumbar vertebrae and a large abscess. Acid-fast bacteria were found in gastric juice. Tuberculostatic treatment was started with isoniazid (10 mg/kg), rifampicin (10 mg/kg) and pyrazinamide (30 mg/kg). Two weeks later spondylectomy was performed, the defect being bridged with bone chips from the iliac crest. Four months after the operation, tuberculostatic treatment now being only isoniazid and rifampicin, he was able to partake fully in all activities of his age group.
