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Recombinant tissue plasminogen activator in the treatment of central venous catheter occlusion in children.

Jacobs, B R; Haygood, M; Hingl, J.

J Pediatr ; 139(4): 593-6, 2001 Oct.

Article in English | MEDLINE | ID: mdl-11598611

ABSTRACT

Tissue plasminogen activator was used to treat 228 children with 320 central venous catheter (CVC) occlusion events. Patency was restored in 91% of CVCs after 1 to 3 treatments, with no adverse events. Tissue plasminogen activator is effective in restoring patency to occluded CVCs and is a viable alternative to CVC removal or urokinase treatment.

Subject(s)

Catheterization, Central Venous/adverse effects , Fibrinolytic Agents/therapeutic use , Recombinant Proteins/therapeutic use , Thrombosis/drug therapy , Thrombosis/etiology , Tissue Plasminogen Activator/therapeutic use , Adolescent , Child , Child, Preschool , Female , Humans , Infant , Infant, Newborn , Male , Outcome Assessment, Health Care , Retreatment , Treatment Failure , Vascular Patency/drug effects

ABSTRACT

Subject(s)

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