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Gan To Kagaku Ryoho ; 30(7): 993-7, 2003 Jul.
Article in Japanese | MEDLINE | ID: mdl-12894717

ABSTRACT

We treated five cases for multiple hepatic metastases from gastric cancer with a novel combination of TS-1 and low-dose cisplatinum (CDDP). TS-1 was orally administered at 100 mg/body/day every day or only on weekdays, and 10 mg of CDDP was infused once or twice a week. The efficacy was evaluated by body CT after the treatment. The CT showed more than a 60% reduction of hepatic tumors in four patients. The tumor markers, CEA and CA19-9, were reduced to 10%. The response rate was 80%. Adverse reactions of grade 1 anemia were observed in two patients and grade 1 leucopenia in one patient. The liver function normalized in one patient. The hemoglobin level was increased from 6.8 g/dl to 11.8 g/dl in one patient. In conclusion, this combined chemotherapy of TS-1 and low-dose CDDP proved useful for advanced gastric cancer patients with multiple hepatic metastases, in view of its therapeutic efficacy, patients' quality of life and low toxicity.


Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Liver Neoplasms/drug therapy , Liver Neoplasms/secondary , Stomach Neoplasms/drug therapy , Stomach Neoplasms/pathology , Administration, Oral , Aged , Cisplatin/administration & dosage , Drug Administration Schedule , Drug Combinations , Humans , Infusions, Intravenous , Male , Middle Aged , Oxonic Acid/administration & dosage , Pyridines/administration & dosage , Tegafur/administration & dosage
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