Does alcohol craving decrease with increasing age? Results from a cross-sectional study.

OBJECTIVE: Long-term studies on patients with impulsive behavior have shown a decrease of symptoms with increasing age. Alcohol craving has many analogies in psychopathology with obsessive-compulsive behavior patterns. The aim of the present study was to find evidence of a possible decrease of craving in elderly alcohol-dependent patients. METHOD: One hundred ninety-eight alcohol-dependent patients at the beginning of alcohol withdrawal therapy were included in this study. The extent of craving was measured using the Obsessive Compulsive Drinking Scale on the day of hospital admission before starting the detoxification regime and 1 week after admission. RESULTS: Linear regression analysis showed a significant negative association between craving and age after 1 week of treatment (no association at admission). T test for independent samples confirmed lower obsessive-compulsive craving in older patients. CONCLUSIONS: The lack of association between craving and age at the beginning of the detoxification can be explained by the influence of other different (e.g., neurobiological) parameters during acute withdrawal. At the end of the physical detoxification after 1 week of treatment, a significant negative association between patient's age and Obsessive Compulsive Drinking Scale score occurred, which points to a decrease of alcohol craving in later years. Alterations in endocrinological functions or in mesolimbic neurotransmission are discussed as possible reasons for this finding.

The pharmacology of lysergic acid diethylamide: a review.

Lysergic acid diethylamide (LSD) was synthesized in 1938 and its psychoactive effects discovered in 1943. It was used during the 1950s and 1960s as an experimental drug in psychiatric research for producing so-called "experimental psychosis" by altering neurotransmitter system and in psychotherapeutic procedures ("psycholytic" and "psychedelic" therapy). From the mid 1960s, it became an illegal drug of abuse with widespread use that continues today. With the entry of new methods of research and better study oversight, scientific interest in LSD has resumed for brain research and experimental treatments. Due to the lack of any comprehensive review since the 1950s and the widely dispersed experimental literature, the present review focuses on all aspects of the pharmacology and psychopharmacology of LSD. A thorough search of the experimental literature regarding the pharmacology of LSD was performed and the extracted results are given in this review. (Psycho-) pharmacological research on LSD was extensive and produced nearly 10,000 scientific papers. The pharmacology of LSD is complex and its mechanisms of action are still not completely understood. LSD is physiologically well tolerated and psychological reactions can be controlled in a medically supervised setting, but complications may easily result from uncontrolled use by layman. Actually there is new interest in LSD as an experimental tool for elucidating neural mechanisms of (states of) consciousness and there are recently discovered treatment options with LSD in cluster headache and with the terminally ill.