Sex specific influence on the relationship between maternal exposures to persistent chemicals and birth outcomes.

Prenatal exposure to persistent pollutants has been associated with adverse birth outcomes, although few studies have investigated the influence of the sex of the infant. Sex specific differences have been associated with neurobehavioural impacts from environmental exposures with limited and contrary findings in relation to persistent pollutants. This study investigated the relationships between maternal exposure to a range of metals, polychlorinated biphenyls and pesticides measured in biological samples and birth outcomes with a specific focus on the sex of the infant. Outcome measures used included birth weight, birth length and head circumference, proportion of optimal birth weight (POBW), proportion of optimal birth length, proportion of optimal head circumference (POHC) and ponderal index. In general maternal urinary and blood metals, plasma polychlorinated biphenyl and pesticide concentrations were low. In adjusted regression models, a ln-unit increase in plasma ß-hexachlorocyclohexane concentrations was associated with decreased birth weight (-76g, 95% CI -149, -33), ponderal index (-0.048, 95% CI 0.102, 0.007) and proportion of optimal birth weight (-1.5%, 95% CI -3.6, 0.5) in the whole study population, with stronger associations observed for male infants. Maternal p,p'-dichlorodiphenyldichloroethylene concentrations were associated with reduced ponderal index in male infants (ß=-0.171, 95% CI -0.269, -0.074). A ln-unit increase in plasma hexachlorobenzene concentrations was associated with a 5% increase in POBW in male infants (95% CI 0.67, 9.5). Increased urinary barium was associated with increased birth length and POBL and decreased ponderal index in boys. Conversely, urinary concentrations of caesium and rubidium were found to be associated with decreased foetal growth in female infants. This study supports the growing body of evidence regarding the reductions in foetal growth associated with ß-hexachlorocyclohexane and p,p'-Dichlorodiphenyldichloroethylene as well as reporting new relationships between metals exposures and birth outcomes. The finding that maternal exposure to barium, strontium, rubidium and caesium was associated with birth outcomes requires confirmation in larger studies. Similarly the apparent differences in susceptibility based on sex of the infant requires further investigation.

Urinary bisphenol A concentrations in pregnant women.

Bisphenol A is a chemical that is present in a number of products and types of food packaging. Prenatal exposure to bisphenol A may cause behavioural changes in young children. The aim of this study was to investigate exposure to bisphenol A in pregnant Australian women as a surrogate of neonatal exposure. First morning void urine samples were collected from 26 pregnant women at around week 38 of gestation. Bisphenol A was detectable in 85% of the samples analysed. The median concentration in this group of women was 2.41µg/L with a range of

Children's exposure to metals: a community-initiated study.

In 2007, it was shown that the shipping of lead (Pb) through Esperance Port in Western Australia resulted in contamination and increased Pb concentrations in children. A clean-up strategy was implemented; however, little attention was given to other metals. In consultation with the community, a cross-sectional exposure study was designed. Thirty-nine children aged 1 to 12 years provided samples of hair, urine, drinking water, residential soil and dust. Concentrations of nickel (Ni) and Pb were low in biological and environmental samples. Hair aluminium (Al) (lower than the detection limit [DL] to 251 µg/g) and copper (Cu) (7 to 415 µg/g), as well as urinary Al (

Acid sulphate soil disturbance and metals in groundwater: implications for human exposure through home grown produce.

A significant emerging environmental problem is the disturbance and oxidation of soils with high levels of iron sulphide minerals resulting in acidification and causing the mobilization of metals into groundwater. This process is occurring in many parts of the world. In Western Australia, impacted groundwater is extracted by residents for domestic use. We sought to establish domestic use patterns of bore water and the concentration of metals. Sixty-seven domestic bore water samples clearly indicated oxidation of sulphidic materials with heavy metal concentrations ranging for aluminium (