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1.
Psychogeriatrics ; 17(6): 453-459, 2017 Nov.
Article in English | MEDLINE | ID: mdl-29178502

ABSTRACT

BACKGROUND: It is widely supposed that there has been no evidence of increased survival in patients with advanced dementia receiving enteral tube feeding. However, more than a few studies have reported no harmful outcome from tube feeding in dementia patients compared to in patients without dementia. METHODS: This was a retrospective study. Nine psychiatric hospitals in Okayama Prefecture participated in this survey. All inpatients fulfilling the entry criteria were evaluated. All subjects suffered from difficulty with oral intake. Attending physicians thought that the patients could not live without long-term artificial nutrition. The physicians decided whether to make use of long-term artificial nutrition between January 2012 and December 2014. RESULTS: We evaluated 185 patients. Their mean age was 76.6 ± 11.4 years. Of all subjects, patients with probable Alzheimer's disease (n = 78) formed the biggest group, schizophrenia patients (n = 44) the second, and those with vascular dementia (n = 30) the third. The median survival times were 711 days for patients with tube feeding and 61 days for patients without tube feeding. In a comparison different types of tube feeding, median survival times were 611 days for patients with a nasogastric tube and more than 1000 days for those with a percutaneous endoscopic gastrostomy tube. CONCLUSION: Patients with tube feeding survived longer than those without tube feeding, even among dementia patients. This study suggests that enteral nutrition for patients with dementia prolongs survival. Additionally, percutaneous endoscopic gastrostomy tube feeding may be safer than nasogastric tube feeding among patients in psychiatric hospitals.


Subject(s)
Dementia/mortality , Dementia/therapy , Hospitals, Psychiatric , Inpatients/statistics & numerical data , Intubation, Gastrointestinal/methods , Mental Disorders/mortality , Mental Disorders/therapy , Nutritional Status , Aged , Aged, 80 and over , Dementia/diagnosis , Enteral Nutrition , Female , Humans , Japan/epidemiology , Long-Term Care/methods , Male , Mental Disorders/diagnosis , Multivariate Analysis , Proportional Hazards Models , Retrospective Studies , Schizophrenia/diagnosis , Schizophrenia/mortality , Schizophrenia/therapy , Sex Distribution , Survival Analysis , Survival Rate , Treatment Outcome
2.
BMC Geriatr ; 17(1): 267, 2017 Nov 21.
Article in English | MEDLINE | ID: mdl-29157223

ABSTRACT

BACKGROUND: It is widely supposed that there is no benefit, including extended survival and decreased rate of pneumonia, in patients with severe dementia receiving enteral tube feeding (TF). However, there have been few studies comparing the frequency of pneumonia before and after TF in severe dementia. METHODS: Nine psychiatric hospitals in Okayama Prefecture participated in this retrospective survey. All inpatients fulfilling the entry criteria were evaluated. All subjects suffered from difficulty in oral intake. Attending physicians thought that the patients could not live without long-term artificial nutrition, and they decided whether or not to make use of long-term artificial nutrition from January 1, 2014 to December 31, 2014. RESULTS: We evaluated 58 patients including 46 with TF and 12 without. The mean age of all patients was 79.6 ± 9.0 years old. Patients with probable Alzheimer's disease (n = 38) formed the biggest group, and those with vascular dementia the second (n = 14). Median survival times were 23 months among patients with TF and two months among patients without TF. The start of TF decreased the frequency of pneumonia and the use of intravenous antibiotics. CONCLUSIONS: TF decreased pneumonia and antibiotic use, even in patients with severe dementia. The results of this study do not necessarily indicate that we should administer TF to patients with severe dementia. We should consider the quality of life of patients carefully before deciding the use or disuse of TF for patients with severe dementia.


Subject(s)
Alzheimer Disease/therapy , Dementia, Vascular/therapy , Enteral Nutrition/methods , Pneumonia, Aspiration/prevention & control , Aged , Aged, 80 and over , Alzheimer Disease/mortality , Alzheimer Disease/psychology , Dementia, Vascular/mortality , Dementia, Vascular/psychology , Enteral Nutrition/adverse effects , Enteral Nutrition/mortality , Enteral Nutrition/psychology , Female , Humans , Incidence , Male , Nutritional Status , Pneumonia, Aspiration/mortality , Pneumonia, Aspiration/psychology , Quality of Life/psychology , Retrospective Studies , Survival Rate
3.
Int Psychogeriatr ; 24(1): 28-37, 2012 Jan.
Article in English | MEDLINE | ID: mdl-21843399

ABSTRACT

BACKGROUND: Early detection of dementia will be important for implementation of disease-modifying treatments in the near future. We aimed to investigate the diagnostic validity and reliability of the Japanese version of the revised Addenbrooke's Cognitive Examination (ACE-R J) for identifying mild cognitive impairment (MCI) and dementia. METHODS: We translated and adapted the original ACE-R for use with a Japanese population. Standard tests for evaluating cognitive decline and dementing disorders were applied. A total of 242 subjects (controls = 73, MCI = 39, dementia = 130) participated in this study. RESULTS: The optimal cut-off scores of ACE-R J for detecting MCI and dementia were 88/89 (sensitivity 0.87, specificity 0.92) and 82/83 (sensitivity 0.99, specificity 0.99) respectively. ACE-R J was superior to the Mini-Mental State Examination in the detection of MCI (area under the curve (AUC): 0.952 vs. 0.868), while the accuracy of the two instruments did not differ significantly in identifying dementia (AUC: 0.999 vs. 0.993). The inter-rater reliability (ICC = 0.999), test-retest reliability (ICC = 0.883), and internal consistency (Cronbach's α = 0.903) of ACE-R J were excellent. CONCLUSION: ACE-R J proved to be an accurate cognitive instrument for detecting MCI and mild dementia. Further neuropsychological evaluation is required for the differential diagnosis of dementia subtypes.


Subject(s)
Cognitive Dysfunction/diagnosis , Dementia/diagnosis , Neuropsychological Tests/standards , Aged , Alzheimer Disease/diagnosis , Case-Control Studies , Diagnosis, Differential , Female , Humans , Japan , Male , Memory Disorders/diagnosis , Reproducibility of Results , Sensitivity and Specificity , Translating
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