1.
Intern Med
; 55(16): 2197-202, 2016.
Article
in English
| MEDLINE
| ID: mdl-27522994
ABSTRACT
Intimal sarcoma is a rare disease with a poor prognosis. We herein report the case of a 71-year-old man with intimal sarcoma of the pulmonary artery treated with pazopanib. The tumor showed regression after 1 month of treatment. Hand-foot syndrome led to cessation of pazopanib, which triggered a disease flare. Pazopanib should be considered in patients with intimal sarcoma of the pulmonary artery that is unresectable or recurrent after surgery or cytotoxic chemotherapy. We must be careful about drug cessation, as it can lead to a disease flare.
Subject(s)
Angiogenesis Inhibitors/therapeutic use , Pulmonary Artery/pathology , Pyrimidines/therapeutic use , Sulfonamides/therapeutic use , Tunica Intima/pathology , Vascular Neoplasms/drug therapy , Vascular Neoplasms/pathology , Aged , Angiogenesis Inhibitors/adverse effects , Hand-Foot Syndrome/etiology , Humans , Indazoles , Male , Pyrimidines/adverse effects , Sulfonamides/adverse effects
2.
Nihon Naika Gakkai Zasshi
; 104(12): 2556-61, 2015 12 10.
Article
in Japanese
| MEDLINE
| ID: mdl-28530372