ABSTRACT
In Okinawa, there were ten cases (7 male and 3 female) of subacute sclerosing panencephalitis (SSPE) from 1970 to 1996. All cases had a history of measles and none had received measles vaccination. The incidence of SSPE in Okinawa was 0.31 per million in 1970-1996. Being higher than other districts in Japan. Two cases contracted measles in 1973 and other three in 1990, showing a tendency to cluster.
Subject(s)
Subacute Sclerosing Panencephalitis/epidemiology , Age Factors , Child , Child, Preschool , Female , Humans , Incidence , Infant , Japan/epidemiology , Male , Measles/epidemiology , Measles/prevention & control , Measles Vaccine , Time Factors , Vaccination/statistics & numerical dataABSTRACT
We studied sixty-three children of severe motor and intellectual disabilities syndrome aged between 3 and 5 years, who live in Okinawa. Severe motor and intellectual disabilities syndrome were defined as those who belong to classes 1 approximately 4 of Ohshima's classification (incapable of walking with IQs not more than 35). The prevalence rate was about 1.12/1,000 live births. Forty-four% of the total children belonged to class 1 of Ohshima's classification (bedridden and IQs less than 20). The factors were: congenital 31.7%, perinatal 38.1%, postnatal 14.3%, and unknown 15.9%. The perinatal factor was still relatively high as compared with the others.
Subject(s)
Disabled Persons , Intellectual Disability/epidemiology , Psychomotor Disorders/epidemiology , Child, Preschool , Female , Humans , Japan/epidemiology , Male , Prevalence , SyndromeABSTRACT
A primigravida delivered a cyanosed female infant with a very low Apgar score. Cardiac anomaly of the fetus was detected at 32 weeks of gestation by ultrasonography. The baby died on the day of delivery. Autopsy revealed multiple tumor masses in the interventricular septum and ventricular walls. The tumor originating from the interventricular septum was the largest and measured 3.7 x 3 cm. Histologically, the tumor was composed of large polygonal glycogen-laden cells and 'spider-cells'. Eosinophilic giant histiocytic cells were also observed in the spleen. Ultrastructural features of the tumor cells correlated with those of typical cardiac muscle cells.
Subject(s)
Fetal Diseases , Heart Neoplasms , Rhabdomyoma , Fatal Outcome , Female , Fetal Diseases/diagnosis , Fetal Diseases/diagnostic imaging , Fetal Diseases/pathology , Heart Neoplasms/diagnosis , Heart Neoplasms/diagnostic imaging , Heart Neoplasms/pathology , Humans , Infant, Newborn , Myocardium/pathology , Myocardium/ultrastructure , Pregnancy , Rhabdomyoma/diagnosis , Rhabdomyoma/diagnostic imaging , Rhabdomyoma/pathology , Ultrasonography, PrenatalSubject(s)
Electroencephalography , Epilepsy, Generalized/physiopathology , Adolescent , Adult , Cerebral Cortex/physiopathology , Child , Child, Preschool , Epilepsy, Generalized/classification , Evoked Potentials/physiology , Female , Humans , Infant , Male , Prognosis , Spasms, Infantile/classification , Spasms, Infantile/physiopathology , SyndromeABSTRACT
The spontaneous epithelioma of the Japanese newt, Cynops pyrrhogaster, is a useful animal model for study of development and regression of papillomata of suspected viral origin. Therefore, ultrastructural studies of this cutaneous tumor were undertaken in order to characterize this model further. The ultrastructure of normal Cynops pyrrhogaster epidermis resembled teleost more than anuran epidermis. Surface cells of the bilayered stratum corneum were covered by micro-ridges and contained prominent nuclei, unlike the stratum corneum of mammals. Capillary endothelial cells contained unique small dense granules. Principal changes in tumors consisted of hyperplasia of stratum granulosum cells, increased melanin bodies in corneal cells, distorted configurations and aberrant location of outer corneal cells, which also demonstrated irregularity of micro-ridges and increased mucin and vacuole content. Intercellular spaces were enlarged between all cell types. Virus-like particles were observed in approximately 40 percent of tumors, particularly in the middle of the tumor.
