ABSTRACT
Underestimating antimicrobial use based on days of therapy (DOT) is recognized for certain antimicrobial agents. We investigated the difference between DOT and therapeutic drug monitoring (TDM)-based exposure days in estimating vancomycin use and demonstrated that DOT may underestimate vancomycin exposure by â¼10%.
Subject(s)
Anti-Bacterial Agents/administration & dosage , Drug Monitoring/methods , Vancomycin/administration & dosage , Anti-Bacterial Agents/therapeutic use , Drug Monitoring/statistics & numerical data , Humans , Inpatients/statistics & numerical data , Retrospective Studies , Vancomycin/therapeutic useABSTRACT
Pectin liquid, "REF-P1" is supposed to make the enteral formula semi-solid in the stomach. The consequence after injecting "REF-P1" and the enteral formula into the stomach was observed under gastric endoscopy. When the acidity of gastric juice was stronger than pH 2, "REF-P1" reacted with the gastric juice and was solidified into a hard gel. The general feature of the formula was uneven with the liquid and minute hard gel formation. On the other hand, when the acidity was weak, "REF-P1" and the formula were mixed together, pectin liquid was transformed to the regular soft gel. The feature of the semi-solid formula with "REF-P1" depends on the acidity of gastric juice.
