ABSTRACT
The basic cancer pain management at our hospitalis based on WHO Cancer Pain Treatment Method-Opioid together with NSAIDs. We investigated 48 patients who were administered an opioid as management of cancer pain for three (3) months from May to July in 2008. Consequently, we found that 20 out of the 48 patients (41.7%) used an opioid together with NSAIDs. Meanwhile, we also investigated constipation and digestive impediment as side effects caused from opioid and NSAIDs, respectively. Of the 20 patients, 12 patients (60%) used laxative for constipation, and 18 patients (90%) used a digestive ulcer treatment drug for digestive impediment. Ten (20.8%) of the 48 patients used all 4 drugs-opioid, NSAIDs, laxative and digestive ulcer treatment drugs. As a result, we decided to further examine cancer pain management at our hospital.
Subject(s)
Analgesics, Opioid/administration & dosage , Neoplasms/physiopathology , Pain, Intractable/drug therapy , Analgesics, Opioid/adverse effects , Anti-Inflammatory Agents, Non-Steroidal , Constipation/chemically induced , Constipation/drug therapy , Drug Administration Schedule , Female , Humans , Male , Stomach Ulcer/chemically induced , Stomach Ulcer/drug therapyABSTRACT
We investigated c-Met expression in cultured astrocytes and their regulation by cytokines. Immunocytochemistry revealed that c-Met was expressed in cultured astrocytes. Western blotting revealed that acidic and basic fibroblast growth factor (FGF) enhanced and hepatocyte growth factor (HGF) reduced c-Met expression. Reverse transcription-polymerase chain reaction revealed that FGFs and HGF enhanced c-met expression. These findings suggest that c-Met expressed in astrocytes may have important roles during the nervous system regeneration.
