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1.
Nihon Kyobu Shikkan Gakkai Zasshi ; 35(1): 22-9, 1997 Jan.
Article in Japanese | MEDLINE | ID: mdl-9071152

ABSTRACT

We studied 5 patients with acute eosinophilic pneumonia. Radiologic findings were Kerley's lines and pleural effusion on chest X-ray films, and interlobular septa on chest CT scans. Examination of transbronchial lung biopsy specimens revealed infiltration of eosinophils and lymphocytes into alveolar walls and edema of alveolar walls, interlobular septa, and perivascular connective tissue. The findings of interstitial edema were consistent with the radiological findings. Epithelial damage and bud-type intraluminal fibrosis were also seen, but residual alveolar structure was maintained. Bronchoalveolar lavage fluid contained abnormally high percentages of eosinophils and lympocytes. It also contained basophils and mast cells, which were not seen in fluid from normal subjects. Fluid from patients with chronic eosinophilic pneumonia had significantly fewer basophils than did fluid from those with acute eosinophilic pneumonia (p < 0.01). These findings suggest that release of chemical mediators from basophils plays a key role in interstitial edema in acute eosinophilic pneumonia.


Subject(s)
Pulmonary Eosinophilia/pathology , Acute Disease , Adult , Bronchoalveolar Lavage Fluid , Female , Humans , Lung/pathology , Male , Middle Aged
2.
Intern Med ; 33(5): 271-6, 1994 May.
Article in English | MEDLINE | ID: mdl-7949629

ABSTRACT

In 93 patients with inoperable non-small cell lung carcinoma who underwent chemotherapy including cisplatin, the prognostic value of 9 factors were determined using Cox's proportional hazard model. Univariate analysis revealed that patients with a performance status of grade 2 (p < 0.01) or 3 (p < 0.05), those with stage IV disease (p < 0.05), those with a serum neuron specific enolase (NSE) level > 7.0 ng/ml (p < 0.001), and those with a low serum albumin level (p < 0.05) had a significantly worse prognosis. Multivariate analysis showed that a performance status of 2 or 3 and a high NSE serum level were associated with a significantly worse prognosis. More attention should be paid to the serum NSE level in patients with non-small cell lung carcinoma, because it not only reflects the tumor volume, but is also a prognostic factor which is dependent on individual tumor characteristics.


Subject(s)
Carcinoma, Non-Small-Cell Lung/enzymology , Lung Neoplasms/enzymology , Phosphopyruvate Hydratase/blood , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Multivariate Analysis , Prognosis
3.
Gan To Kagaku Ryoho ; 20(1): 34-41, 1993 Jan.
Article in Japanese | MEDLINE | ID: mdl-8093658

ABSTRACT

Microtubules are among the most strategic subcellular targets of anticancer agents. Recently, new antimicrotubule agents have been introduced to clinical cancer chemotherapy. Navelbine is a new derivative of vinca alkaloids, which especially has an activity against NSCLC. Unlike classical anti-microtubules agents like colchitine and vinca alkaloids, which induce depolymerization of microtubules, taxol has an unique mechanism of action which induces tubulin polymerization. Taxotere, an analogue of taxol is slightly more active as a promoter of tubulin polymerization than Taxol. E7010 is a novel sulfonamide that inhibits tubulin polymerization. Results of preclinical and clinical studies of these agents are reviewed.


Subject(s)
Antineoplastic Agents/therapeutic use , Microtubules/drug effects , Taxoids , Vinblastine/analogs & derivatives , Aminophenols/pharmacology , Aminophenols/therapeutic use , Animals , Antineoplastic Agents/pharmacology , Carcinoma, Non-Small-Cell Lung/drug therapy , Docetaxel , Humans , Leukemia, Experimental/drug therapy , Lung Neoplasms/drug therapy , Mice , Paclitaxel/analogs & derivatives , Paclitaxel/pharmacology , Paclitaxel/therapeutic use , Sulfonamides/pharmacology , Sulfonamides/therapeutic use , Vinblastine/pharmacology , Vinblastine/therapeutic use , Vinorelbine
4.
Gan To Kagaku Ryoho ; 18(6): 1031-8, 1991 May.
Article in Japanese | MEDLINE | ID: mdl-2029188

ABSTRACT

We thought that nutritional parameters in laboratory data might be able to express quality of life (QOL). Therefore, in 70 patients with malignant chest diseases (NSCLC, 42 patients; SCLC, 15; lung metastasis, 7; others, 6), the correlation between nutritional parameters of total protein (Tp), serum albumin (Alb), and serum (cholinesterase (ChE] and Karnofsky Performance Status scale (KPS) was investigated. Then, in 24 patients with them (NSCLC, 12; SCLC, 6; lung metastasis, 4; others 2), Alb and ChE were compared to the EORTC Core Quality of Life Questionnaire and Lung Cancer-Specific Questionnaire Module (QS). Results were as follows: 1) KPS and nutritional parameters correlated (Tp. r = 0.55, p less than 0.001; Alb, r = 0.60, p less than 0.001, ChE, r = 0.60; p less than 0.001). 2) The cores for Functional Status (FS) and Disease and Treatment-related symptoms (Sym) in QS and parameters of Alb and ChE correlate (FS v.s. Alb, p less than 0.01; Sym v.s. Alb, p less than 0.01; FS v.s. ChE, p less than 0.05; and Sym v.s. ChE, p less than 0.05). Moreover, the scores of Psychological Distress in QS and Alb showed a correlation (p less than 0.05). It is considered that nutrition and part of QOL (KPS and FS + Sym in QS, that is to say, "objective" functional activity and "subjective" functional activity and symptoms) correlate, and that nutritional parameters are useful to evaluate QOL.


Subject(s)
Neoplasms/rehabilitation , Nutritional Physiological Phenomena , Quality of Life , Humans , Lung Neoplasms/psychology , Lung Neoplasms/rehabilitation , Neoplasms/psychology , Nutrition Assessment , Serum Albumin/analysis , Surveys and Questionnaires
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