Calibration of sodium iodide detectors and reentrant ionization chambers for 212Pb activity in different geometries by HPGe activity determined samples.

Lead-212 is a promising radionuclide for cancer therapy, but no primary 212Pb activity standardization has been published. A need therefore exists for accurate estimation of injected doses of 212Pb activity in equilibrium with progeny, when it comes to preclinical and clinical trials. In this study, 212Pb activity was determined using a high purity germanium (HPGe) detector, which allowed the determination of geometry-specific calibration factors for commercially available reentrant ionization chambers (ICs) and sodium iodide (NaI) detectors.

Radionuclide calibrator responses for 224Ra in solution and adsorbed on calcium carbonate microparticles.

A suspension of 224Ra adsorbed onto CaCO3 microparticles shows promise for α-therapy of intracavitary micro-metastatic diseases. To facilitate accurate activity administrations, geometry-specific calibration factors for commercially available reentrant ionization chambers (ICs) have been developed for 224RaCl2 solutions and 224Ra adsorbed onto CaCO3 microparticles in suspension in ampoules, vials, and syringes. Ampoules and vials give IC responses consistent with each other to <1%. Microparticles attenuation leads to a ≈1% to ≈2.5% reduction in response in the geometries studied.