Surface-Enhanced Absorption Spectroscopy for Optical Fiber Sensing.

Visible and near-infrared spectroscopy are widely used for sensing applications but suffer from poor signal-to-noise ratios for the detection of compounds with low concentrations. Enhancement by surface plasmon resonance is a popular technique that can be utilized to increase the signal of absorption spectroscopy due to the increased near-field created close to the plasmons. Despite interest in surface-enhanced infrared absorption spectroscopy (SEIRAS), the method is usually applied in lab setups rather than real-life sensing situations. This study aimed to achieve enhanced absorption from plasmons on a fiber-optic probe and thus move closer to applications of SEIRAS. A tapered coreless fiber coated with a 100 nm Au film supported signal enhancement at visible wavelengths. An increase in absorption was shown for two dyes spanning concentrations from 5 × 10-8 mol/L to 8 × 10-4 mol/L: Rhodamine 6G and Crystal Violet. In the presence of the Au film, the absorbance signal was 2-3 times higher than from an identically tapered uncoated fiber. The results confirm that the concept of SEIRAS can be implemented on an optical fiber probe, enabling enhanced signal detection in remote sensing applications.

Glucose sensing by absorption spectroscopy using lensed optical fibers.

The bulkiness of common transmission spectroscopy probes prevents applicability at remote locations such as within the body. We present the fabrication and characterization of lensed fibers for transmission spectroscopy in the near-infrared. Eigenmode simulations and measurements of the coupling efficiency are presented and applied to design the setup corresponding to the sample absorption. Sensing capabilities are demonstrated on aqueous glucose samples ranged 80 to 500 mM, obtaining a mean absolute percentage error of calibration of 4.3%. With increased flexibility, transmission spectroscopic sensors at remote locations may be achievable, for example, applied to in vivo continuous glucose monitoring.

Micro-lensed optical fibers for a surface-enhanced Raman scattering sensing probe.

We present the fabrication and characterization of a novel sensing configuration based on surface-enhanced Raman scattering (SERS) and two micro-lensed optical fibers. The first micro-lensed fiber is used to excite surface plasmon resonance in a gold film deposited over a mono-layer of nano-sphere surface (AuFON), and the second lensed fiber is used to collect the SERS signal. The sensing capabilities of the fabricated device are demonstrated by measuring different concentrations of Rhodamine 6G in a water solution.

Blood glucose control using a novel continuous blood glucose monitor and repetitive intravenous insulin boluses: exploiting natural insulin pulsatility as a principle for a future artificial pancreas.

The aim of this study was to construct a glucose regulatory algorithm by employing the natural pulsatile pattern of insulin secretion and the oscillatory pattern of resting blood glucose levels and further to regulate the blood glucose level in diabetic pigs by this method. We developed a control algorithm based on repetitive intravenous bolus injections of insulin and combined this with an intravascular blood glucose monitor. Four anesthetized pigs were used in the study. The animals developed a mildly diabetic state from streptozotocin pretreatment. They were steadily brought within the blood glucose target range of 4.5-6.0 mmol/L in 21 to 121 min and kept within that range for 128 to 238 min (hypoglycemic values varied from 2.9 to 51.1 min). The study confirmed our hypotheses regarding the feasibility of this new principle for blood glucose control, and the algorithm was constantly improved during the study to produce the best results in the last animals. The main obstacles were the drift of the IvS-1 sensor and problems with the calibration procedure, which calls for an improvement in the sensor stability before this method can be applied fully in new studies in animals and humans.

Continuous measurement of blood glucose: validation of a new intravascular sensor.

BACKGROUND: Tight blood glucose control is used extensively in perioperative and critically ill patients. Several studies, however, have shown contradictory effects on patient outcomes. A major problem of these studies has been inadequate control of the prime variable, blood glucose. This paper describes the validation of a new intravascular continuous blood glucose sensor. METHODS: The glucose sensor was placed in the superior caval vein of seven anesthetized pigs. Sensor readings were compared with arterial blood gas readings. Fluctuations in blood glucose were created using intravenous glucose and insulin. A total of 807 paired sensor and blood gas readings were obtained. RESULTS: The sensor was tested with a range of blood glucose values (0.63-15.75 mM [mean bias, 0.0131 mM]). Analysis using Bland-Altman plots yielded 95% limits of agreement at -0.908 and 0.934 mM. There were 121 paired measurements with a mean value below 2.2 mM, yielding 95% limits of agreement at -0.553 and 0.466 mM. CONCLUSIONS: The performance of the sensor was in agreement with blood gas measurements in a wide range of glucose values. For the clinician, it is noteworthy that performance was equally good in the hypoglycemic area.

Real-time phase tracking in single-photon interferometers.

A new technique for phase tracking in quantum cryptography systems is proposed that adjusts phase in an optimal way, using only as many photon counts as necessary. We derive an upper bound on the number of photons that need to be registered during phase adjustment to achieve a given phase accuracy. It turns out that most quantum cryptosystems can successfully track phase on a single-photon level, entirely with software, without any additional hardware components or extensive phase-stabilization measures. The technique is tested experimentally on a quantum cryptosystem.