ABSTRACT
INTRODUCTION: Nasal NK/T-cell lymphoma is a rare but well-known clinical entity. Thanks to improvements in anatomopathology and the development of routine immunohistochemistry, the diagnosis of nasal NK/T-cell lymphoma (NK for "natural killer") was recognized by the WHO in 2001. The main differential diagnosis is with Wegener's granulomatosis. Treatment is based on radiotherapy and chemotherapy. Prognosis is poor, with variable evolution and sometimes rapid progression. CASE REPORT: The authors report the case of a 54-year-old man without known pathological history, who presented with bilateral nasal obstruction with purulent rhinorrhea. Diagnosis was made on the basis of immunohistochemical study of biopsy samples. The tumor was graded IE on the Ann Arbor classification. Treatment, comprising CHOP chemotherapy followed by radiotherapy, achieved total remission at 8 months' follow-up. DISCUSSION/CONCLUSION: Sinonasal NK/T-cell lymphoma is rare. Diagnosis is based on immunophenotypic and molecular characteristics. It is an aggressive lymphoma, requiring multidisciplinary management. Prognosis is poor.
Subject(s)
Lymphoma, Extranodal NK-T-Cell/pathology , Lymphoma, Extranodal NK-T-Cell/therapy , Maxillary Sinus Neoplasms/pathology , Maxillary Sinus Neoplasms/therapy , Nose Neoplasms/pathology , Nose Neoplasms/therapy , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Biopsy , Chemotherapy, Adjuvant/methods , Diagnosis, Differential , Follow-Up Studies , Humans , Lymphoma, Extranodal NK-T-Cell/diagnosis , Male , Maxillary Sinus Neoplasms/diagnosis , Middle Aged , Neoplasm Grading , Neoplasm Invasiveness , Nose Neoplasms/diagnosis , Prognosis , Radiotherapy, Adjuvant/methods , Rare Diseases , Treatment OutcomeABSTRACT
INTRODUCTION: Head and neck hydatid disease is rare, even in countries in which echinococcosis is endemic and accounts for 1% of all human echinococcosis sites. The purpose of this report is to describe the epidemiology, clinical features, complementary investigations and treatment of head and neck hydatid disease in the light of a case report and a review of the literature. CASE REPORT: The authors report the case of a 40-year-old man, who presented with a right supraclavicular mass that had been growing for six months. Neck ultrasound initially suggested a type I unilocular hydatid cyst according to Gharbi's classification. Neck exploration was then performed, revealing a hydatid cyst. DISCUSSION/CONCLUSION: Isolated hydatid cyst of the neck is exceptional, but should be considered in the presence of any cystic mass of the neck in endemic regions. Ultrasound facilitates diagnostic and therapeutic procedures in order to ensure complete surgical resection. Prevention remains the essential treatment.
