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Angew Chem Int Ed Engl ; 52(47): 12298-302, 2013 Nov 18.
Article in English | MEDLINE | ID: mdl-24108547

ABSTRACT

It stems from the magnetism: The extraction of stem/progenitor cells from the brain of live animals is possible using antibodies conjugated to magnetic nanoparticles (Ab-MNPs). The Ab-MNPs are introduced to a rat's brain with a superfine micro-syringe. The stem cells attach to the Ab-MNPs and are magnetically isolated and removed. They can develop into neurospheres and differentiate into different types of cells outside the subject body. The rat remains alive and healthy.


Subject(s)
Antibodies/chemistry , Brain/cytology , Cell Separation/methods , Magnetite Nanoparticles/chemistry , Neural Stem Cells/cytology , AC133 Antigen , Animals , Antibodies/immunology , Antigens, CD/immunology , Antigens, CD/metabolism , Cell Separation/instrumentation , Glycoproteins/immunology , Glycoproteins/metabolism , Neural Stem Cells/metabolism , Particle Size , Peptides/immunology , Peptides/metabolism , Rats , Regenerative Medicine
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