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1.
Hong Kong Med J ; 16(6): 493-6, 2010 Dec.
Article in English | MEDLINE | ID: mdl-21135430

ABSTRACT

This report describes a 68-year-old Chinese man who was diagnosed with Good syndrome 6 years after initial presentation when he underwent thymectomy. He presented with recurrent pneumonia, diarrhoea, weight loss, and visual symptoms. Extensive examination for anaemia and neutropenia was done, yet no conclusive diagnosis could be derived. During his last admission for pneumonia, his history of AB thymoma suggested the possibility of Good syndrome. Immunological testing revealed low T cells, absent B cells, and low immunoglobulin M and immunoglobulin G levels. Moreover, he had histologically identified cytomegalovirus pneumonia, cytomegalovirus colitis, and fundoscopic features of cytomegalovirus retinitis. He was treated with a 2-week course of intravenous ganciclovir, lifelong oral valganciclovir, and monthly immunoglobulin infusion. It took 6 years for the diagnosis to be established, therefore, early attention and vigorous search for such potentially treatable conditions in post-thymectomy patients presenting with recurrent infections is recommended.


Subject(s)
Cytomegalovirus Infections/etiology , Diarrhea/etiology , Pneumonia/etiology , Thymectomy/adverse effects , Vision Disorders/etiology , Aged , Humans , Male , Recurrence , Syndrome , Thymoma/surgery , Thymus Neoplasms/surgery
2.
Ann Acad Med Singap ; 34(5): 356-61, 2005 Jun.
Article in English | MEDLINE | ID: mdl-16021225

ABSTRACT

INTRODUCTION: The main aim of this study is to determine the pattern of referrals of poisoning to a tertiary university hospital. The information will be used for poison prevention programme planning, and for educating and awareness promoting to the public. MATERIALS AND METHODS: All patients (under 21 years of age) admitted to the paediatric wards between January 1997 and December 2002 with a discharge diagnosis indicating unintentional (UP) or intentional poisoning (IP) were identified through the computerised discharge information. RESULTS: Sixty males and 98 females accounted for 161 admissions over the 6-year period. Their mean (standard deviation, SD) age was 8.2 (6.2) years. Sixty per cent of admissions involved UP. Females accounted for 47% of the UP but 86% of the IP [odds ratio of females for IP, 7.05; 95% confidence interval (CI) 2.95 to 17.28]. When compared with UP, IP patients were significantly older [mean (SD): 14.9 (1.7) versus 3.6 (3.3) years]. In 70% of the admissions, the patients ingested a single substance. Tablets and pills, especially in the IP adolescents, were more commonly ingested than syrups. The spectrum of substances ingested was vast but paracetamol, cough or cold medicines, and common adult household medications and agents accounted for the majority of medications ingested. The substances ingested were obtained at home in 81 cases (50%) and as over-the-counter medication in 33 (20%). The majority (92%) of patients presented within 24 hours of ingestion. On admission, 63% of UP and 45% of the IP were asymptomatic. No active treatment was required in 65% of patients. In IP, nearly 30% of IP who ingested paracetamol had toxic levels and received N-acteyl cysteine. A history of previous poisoning was more common and subsequent follow-up was offered to 74%. CONCLUSION: Young boys were more at risk of unintentional ingestion whereas adolescent girls were more likely to ingest medications as a gesture of suicide. Paracetamol is a frequently ingested medicinal for which an antidote is available.


Subject(s)
Poisoning/epidemiology , Acetaminophen/poisoning , Child , Child, Preschool , Female , Hospitalization , Humans , Male , Singapore/epidemiology , Suicide, Attempted/statistics & numerical data
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