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Distinguishing Zika and Dengue Viruses through Simple Clinical Assessment, Singapore.

Yan, Gabriel; Pang, Long; Cook, Alex R; Ho, Hanley J; Win, Mar Soe; Khoo, Ai Leng; Wong, Joshua G X; Lee, Chun Kiat; Yan, Benedict; Jureen, Roland; Ho, Siew Seen; Lye, David C; Tambyah, Paul A; Leo, Yee Sin; Fisher, Dale; Oon, Jolene; Bagdasarian, Natasha; Chow, Angela; Smitasin, Nares; Chai, Louis Yi Ann.

Emerg Infect Dis ; 24(8): 1565-1568, 2018 08.

Article in English | MEDLINE | ID: mdl-30016242

ABSTRACT

Dengue virus and Zika virus coexist in tropical regions in Asia where healthcare resources are limited; differentiating the 2 viruses is challenging. We showed in a case-control discovery cohort, and replicated in a validation cohort, that the diagnostic indices of conjunctivitis, platelet count, and monocyte count reliably distinguished between these viruses.

Subject(s)

Dengue/diagnosis , Zika Virus Infection/diagnosis , Adult , Aedes/virology , Aged , Animals , Case-Control Studies , Cohort Studies , Conjunctivitis, Viral/diagnosis , Conjunctivitis, Viral/physiopathology , Conjunctivitis, Viral/virology , Dengue/physiopathology , Dengue/transmission , Dengue/virology , Dengue Virus , Diagnosis, Differential , Female , Fever/diagnosis , Fever/physiopathology , Fever/virology , Humans , Leukocyte Count , Male , Middle Aged , Mosquito Vectors/virology , Myalgia/diagnosis , Myalgia/physiopathology , Myalgia/virology , Platelet Count , ROC Curve , Singapore , Zika Virus , Zika Virus Infection/physiopathology , Zika Virus Infection/transmission , Zika Virus Infection/virology

ABSTRACT

Subject(s)

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