1.
Bioorg Med Chem Lett
; 13(5): 863-5, 2003 Mar 10.
Article
in English
| MEDLINE
| ID: mdl-12617909
ABSTRACT
We describe the docking of selected steroidal and non-steroidal estrone sulphatase inhibitors, including the Phase I clinical trial candidate 667COUMATE (6), into the active site of human carbonic anhydrase II (hCA II). The docking scores are compared with the inhibition of hCA II and show good correlation with biological activity.