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1.
Med J Malaysia ; 74(3): 209-214, 2019 06.
Article in English | MEDLINE | ID: mdl-31256175

ABSTRACT

INTRODUCTION: Chronic kidney disease (CKD) usually has increase of asymmetric dimethylarginine (ADMA) levels. ADMA is a cardiovascular disease (CVD) risk factor and its elevation associated with other CVD risk factors at CKD leads to increasing risk of death. In this article, we aimed to identify levels and elevation proportion of plasma ADMA in CKD as well as association between ADMA with CVD risk factors. METHODS: This cross-sectional study was performed at Hue Central Hospital from 2012-2016 on 176 CKD and 64 control subjects. ADMA levels were measured by using the enzyme linked immunosorbent assay (ELISA) method. RESULTS: Mean ADMA level was markedly higher (p<0.001) in all patients combined (0.73±0.24µmol/L) than in control subjects (0.47±0.13µmol/L). Mean ADMA levels in advanced kidney disease were higher than control subjects. ADMA levels correlated inversely and relatively strictly to estimated glomerular filtration rate (eGFR) (r = -0.689; p<0.001), haemoglobin (r = -0.525; p<0.001) and haematocrit (r = - 0.491; p<0.001); correlated favourably and relatively strictly to serum creatinine (r = 0.569; p<0.001) and serum urea (r = 0.642; p<0.001). ADMA elevation was predicted simultaneously by eGFR<60 mL/min/1.73m2 (p<0.001), anaemia (p=0.002), body mass index (BMI) (p=0.011) and high sensitivity C-reactive protein (hs-CRP) (p=0.041). Cutoff of ≥0.68µmol/L, ADMA levels predict reduction of eGFR<60 mL/min/1.73m2, sensitivity of 86.9 %, specificity of 82.6%, area under ROC 92.4% (95%CI: 88.6-96.1%).


Subject(s)
Arginine/analogs & derivatives , Cardiovascular Diseases/etiology , Renal Insufficiency, Chronic/blood , Renal Insufficiency, Chronic/complications , Adult , Aged , Aged, 80 and over , Arginine/blood , Cardiovascular Diseases/blood , Case-Control Studies , Cross-Sectional Studies , Female , Humans , Male , Middle Aged , Risk Factors , Vietnam
2.
Curr Microbiol ; 76(8): 962, 2019 08.
Article in English | MEDLINE | ID: mdl-29279979

ABSTRACT

The original version of this article unfortunately contained a mistake. The legends of Tables 2 and 3, Fig. 1 are incorrect. The corrected legends are given below.

3.
Curr Microbiol ; 74(2): 203-211, 2017 Feb.
Article in English | MEDLINE | ID: mdl-27942843

ABSTRACT

Extended-spectrum, ß-lactamase-producing Escherichia coli (ESBL-E) harboring the bla CTX-M-55-encoding plasmid (ESBL-E55) has been reported to be associated with urinary tract infection (UTI). The aims of this study were to clarify the prevalence of ESBL-E55 in pork meats and workers from the same wholesale market, as well as patients with UTI from a nearby hospital in Vietnam; we also investigated the plasmids encoding bla CTX-M-55. Sequencing analysis showed that 66.6% of the ESBL-E isolated from pork meats contained bla CTX-M-55, whereas the gene was present in 25.0% of workers and 12.5% of patients with UTI. Plasmid analysis showed that several sizes of plasmid encoded bla CTX-M-55 in ESBL-E55 isolated from pork meats, whereas ESBL-E55 isolated from workers and patients with UTI contained only 104-139 kbp of bla CTX-M-55-encoding plasmids. This indicates that the 104-139 kbp sizes of bla CTX-M-55-encoding plasmids were commonly disseminated in pork meats, wholesale market workers, and patients with UTI.


Subject(s)
Carrier State/microbiology , Escherichia coli Infections/microbiology , Escherichia coli Proteins/genetics , Escherichia coli/enzymology , Meat/microbiology , Plasmids/analysis , Urinary Tract Infections/microbiology , beta-Lactamases/genetics , Escherichia coli/genetics , Escherichia coli/isolation & purification , Escherichia coli Infections/epidemiology , Humans , Molecular Epidemiology , Prevalence , Sequence Analysis, DNA , Vietnam/epidemiology
4.
AJNR Am J Neuroradiol ; 36(10): 1803-9, 2015 Oct.
Article in English | MEDLINE | ID: mdl-26045577

ABSTRACT

Preventive neuroradiology is a new concept supported by growing literature. The main rationale of preventive neuroradiology is the application of multimodal brain imaging toward early and subclinical detection of brain disease and subsequent preventive actions through identification of modifiable risk factors. An insightful example of this is in the area of age-related cognitive decline, mild cognitive impairment, and dementia with potentially modifiable risk factors such as obesity, diet, sleep, hypertension, diabetes, depression, supplementation, smoking, and physical activity. In studying this link between lifestyle and cognitive decline, brain imaging markers may be instrumental as quantitative measures or even indicators of early disease. The purpose of this article is to provide an overview of the major studies reflecting how lifestyle factors affect the brain and cognition aging. In this hot topics review, we will specifically focus on obesity and physical activity.


Subject(s)
Alzheimer Disease/diagnosis , Alzheimer Disease/prevention & control , Cognitive Dysfunction/diagnosis , Cognitive Dysfunction/prevention & control , Diagnostic Imaging , Age Factors , Aged , Aging , Alzheimer Disease/etiology , Brain , Cognitive Dysfunction/etiology , Depression/complications , Diabetes Complications/diagnosis , Humans , Hypertension/complications , Life Style , Research , Risk Factors
5.
J Neuroendocrinol ; 15(3): 289-95, 2003 Mar.
Article in English | MEDLINE | ID: mdl-12588518

ABSTRACT

Early neonatal handling of rat pups produces dampened hypothalamic-pituitary-adrenal axis reactivity to stress in adult male offspring. However, less is known about whether there is a similar effect for females. Although, most studies of neonatal handling have examined subsequent effects during adulthood, adolescence is an important developmental stage for stress responsivity. To address these issues, the effect of neonatal handling on the endocrine stress response and brain activity of male and female rats was determined in response to acute restraint stress during adolescence. Consistent with previous findings in adult males, neonatal handling reduced restraint stress-induced hormone levels in adolescent males. However, in contrast, we found elevated plasma hormone concentrations in handled females. A gender-specific handling effect on brain activity was also evident, with significantly increased stress-induced activation of the posterior cingulate cortex of handled females, as measured by c-fos mRNA expression. The striking gender difference in the effect of early neonatal handling provides evidence that this must be considered as an important variable in subsequent stress responsivity induced by early manipulations.


Subject(s)
Sex Characteristics , Sexual Maturation/physiology , Stress, Physiological/physiopathology , Acute Disease , Adrenocorticotropic Hormone/blood , Age Factors , Animals , Animals, Newborn , Corticosterone/blood , Female , Gyrus Cinguli/growth & development , Gyrus Cinguli/physiology , Male , Pregnancy , Proto-Oncogene Proteins c-fos/genetics , RNA, Messenger/analysis , Rats , Restraint, Physical
6.
Biochem Biophys Res Commun ; 299(4): 634-40, 2002 Dec 13.
Article in English | MEDLINE | ID: mdl-12459186

ABSTRACT

Tetrachlorohydroquinone reductive dehalogenase (PcpC) is the second of three enzymes that catalyze the initial degradation of pentachlorophenol in Sphingomonas sp. UG30 and several other bacterial strains. The UG30 PcpC shares a high degree (94%) of primary sequence identity with the well-studied PcpC from Sphingobium chlorophenolicum ATCC 39723. Significant differences, however, were observed between the two PcpC enzymes in some of their functional and kinetic properties. The temperature optimum of the UG30 PcpC is 10 degrees C higher and the pH optimum is approximately 2 units higher than the S. chlorophenolicum PcpC. In addition, the S. chlorophenolicum PcpC is subject to inhibition by the substrate tetrachlorohydroquinone (TCHQ), and this has necessitated the use of a mutant enzyme, which was not inhibited by TCHQ, for kinetic studies. In contrast, the UG30 PcpC was not inhibited by TCHQ and this may allow detailed kinetic and mechanistic studies using the wild-type enzyme.


Subject(s)
Hydrolases/metabolism , Sphingomonas/enzymology , Amino Acid Sequence , Cloning, Molecular , Humans , Hydrogen-Ion Concentration , Hydrolases/chemistry , Hydrolases/genetics , Hydroquinones/chemistry , Hydroquinones/metabolism , Molecular Sequence Data , Sequence Alignment , Sphingomonas/genetics , Temperature
7.
Ophthalmology ; 104(11): 1875-81, 1997 Nov.
Article in English | MEDLINE | ID: mdl-9373120

ABSTRACT

OBJECTIVE: The purpose of the study is to assess the strengths and weaknesses of selected clinical and radiologic lacrimal tests in patients with epiphora. DESIGN: The study design was a prospective clinical trial. PARTICIPANTS: Fifteen patients with epiphora (N = 27 eyes) were studied. METHODS: All patients underwent Jones testing, the dye disappearance test, canalicular probing, lacrimal scintigraphy, and macrodacryocystography. MAIN OUTCOME MEASURES: The dye disappearance test was graded individually by three ophthalmologists. Lacrimal scintigraphy and macrodacryocystography were evaluated by a nuclear medicine specialist and a radiologist, respectively. A panel of three ophthalmologists evaluated the data using a scoring system that relied on the preponderance of evidence to arrive at a final assessment. RESULTS: When the Jones I test results were negative (dye recovered from the nose), the epiphora was always from hypersecretion. When the Jones I test results were positive (no dye recovered from the nose), obstruction was not always present. When the dye disappearance test results were strongly abnormal, obstruction was always present. In contrast, when the dye disappearance test results were normal, the lacrimal drainage system was not always patent. Canalicular probing was more reliable than scintigraphy in identifying canalicular obstruction. Marked stenosis of the sac or duct on dacryocystography essentially confirmed nasolacrimal outflow obstruction; however, with the authors' technique, a normal study was found in some patients with functional or partial obstruction. CONCLUSIONS: More than one lacrimal test may be required for a definitive diagnosis in patients with epiphora due to partial or functional nasolacrimal outflow obstruction.


Subject(s)
Diagnostic Techniques, Ophthalmological , Lacrimal Apparatus Diseases/diagnosis , Lacrimal Apparatus/diagnostic imaging , Lacrimal Duct Obstruction/diagnosis , Nasolacrimal Duct/diagnostic imaging , Aged , Aged, 80 and over , Contrast Media , Diagnostic Techniques, Ophthalmological/standards , Fluorescein , Humans , Lacrimal Apparatus/physiopathology , Lacrimal Apparatus Diseases/etiology , Lacrimal Apparatus Diseases/physiopathology , Lacrimal Duct Obstruction/complications , Lacrimal Duct Obstruction/physiopathology , Male , Middle Aged , Nasolacrimal Duct/physiopathology , Organotechnetium Compounds , Prospective Studies , Radiographic Image Enhancement , Radionuclide Imaging , Radiopharmaceuticals , Serum Albumin
8.
Neuroimaging Clin N Am ; 4(4): 823-47, 1994 Nov.
Article in English | MEDLINE | ID: mdl-7858922

ABSTRACT

Magnetic resonance imaging is a useful process in the evaluation and follow-up examination of intracranial vascular malformations. Magnetic resonance imaging as related to the four subtypes of these malformations, arteriovenous malformations, venous angiomas, cavernous malformations, and capillary telangiectasis, is discussed.


Subject(s)
Cerebral Angiography , Intracranial Arteriovenous Malformations/diagnosis , Magnetic Resonance Angiography , Tomography, X-Ray Computed , Adolescent , Adult , Aged , Cerebral Hemorrhage/diagnosis , Cerebral Hemorrhage/diagnostic imaging , Cerebrovascular Disorders , Female , Humans , Infant, Newborn , Intracranial Arteriovenous Malformations/diagnostic imaging , Male
9.
Top Magn Reson Imaging ; 6(4): 241-53, 1994.
Article in English | MEDLINE | ID: mdl-7803040

ABSTRACT

The oral cavity is the oral portion of the upper aerodigestive tract separated from the oropharynx by the soft palate, anterior tonsillar pillars, and circumvallate papillae. The anatomy of the components of the oral cavity, including the oral tongue, the floor of the mouth, the retromolar trigone, the hard and soft palates, the buccal mucosa, and the gingiva, are described. The pathology discussion includes both malignant (predominantly squamous cell carcinomas) and benign disease entities commonly detected in this region.


Subject(s)
Magnetic Resonance Imaging , Mouth Diseases/diagnosis , Mouth/pathology , Tongue Diseases/diagnosis , Tongue/pathology , Humans , Mouth Neoplasms/diagnosis , Tongue Neoplasms/diagnosis
10.
AJR Am J Roentgenol ; 150(3): 545-7, 1988 Mar.
Article in English | MEDLINE | ID: mdl-3257606

ABSTRACT

Left latissimus dorsi muscle cardiomyoplasty is a surgical procedure in which the muscle is mobilized as a pedicled flap, moved into the left pleural and mediastinal cavities, and used for surgical repair and/or mechanical augmentation of a failing left ventricle. Chest radiographs in four patients who had undergone this procedure were evaluated. In all four patients, there was bandlike or diffuse increase in density in the left midhemithorax with loss of the left heart border. These findings, which could be misinterpreted as lung disease, represent the transposed muscle flap. CT showed the exact anatomic position of the flap in relation to the intrathoracic structures. Familiarity with the postoperative radiographic appearance of this type of myoplasty is important to avoid misinterpretation.


Subject(s)
Cardiac Surgical Procedures/methods , Surgical Flaps , Aged , Female , Heart/diagnostic imaging , Heart Aneurysm/surgery , Heart Ventricles/surgery , Humans , Male , Middle Aged , Tomography, X-Ray Computed
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