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Environ Pollut ; 339: 122731, 2023 Dec 15.
Article in English | MEDLINE | ID: mdl-37839680

ABSTRACT

Polycyclic aromatic hydrocarbons (PAHs), in particular benzo [a]pyrene (BaP), have been identified as carcinogenic components of tobacco smoke. In mammals, the toxicological response to BaP-diol-epoxide is driven by cytochrome P450 (CYP1A1), a pathway which is absent in Caenorhabditis elegans. In contrast, in worms prominently the CYP-35 enzyme family seems to be induced after BaP exposure. In C. elegans, BaP exposure reduces the accumulation of lysosomal neutral lipids in a dose dependent manner and the deletion of cyp-35A2 results in a significant elevation of neutral lipid metabolism. A cyp-35A2:mCherry;unc-47:GFP dual-labelled reporter strain facilitated the identification of three potential upstream regulators that drive BaP metabolism in worms, namely elt-2, nhr-49 and fos-1. This newly described reporter line is a powerful resource for future large-scale RNAi regarding toxicology and lipid metabolism screens.


Subject(s)
Caenorhabditis elegans Proteins , Carcinogens, Environmental , Animals , Benzo(a)pyrene/toxicity , Benzo(a)pyrene/metabolism , Caenorhabditis elegans/metabolism , Cytochrome P-450 Enzyme System/metabolism , Cytochrome P-450 CYP1A1/metabolism , Lipids , Mammals/metabolism , Caenorhabditis elegans Proteins/genetics , Caenorhabditis elegans Proteins/metabolism , Vesicular Inhibitory Amino Acid Transport Proteins
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