ABSTRACT
Case summary: A 7-month-old female spayed domestic shorthair cat was presented for respiratory distress due to cardiogenic pulmonary edema. Despite initial treatment and oxygen delivery in an oxygen tent, the cat still showed signs of severe respiratory effort and oxygen saturation measured via pulse oximetry was below 85%. Because the owners declined mechanical ventilation, the cat was transitioned to high-flow oxygen therapy (HFOT). HFOT allowed significant improvement of the respiration parameters within 15 mins without causing clinical complications. The cat was briefly anaesthetised for the placement of the nasal cannula on initiation of HFOT, and the interface was well tolerated thereafter. The cat was transitioned to an oxygen cage after 16 h, weaned from oxygen 4 h later and was discharged after 3 days of hospitalisation. Long-term follow-up showed no abnormalities, and the leading hypothesis was transient myocardial thickening. Relevance and novel information: The first use of HFOT in a dyspneic cat is described in this study. HFOT could be a life-saving option for cats with severe hypoxemia or do-not-intubate orders that fail to respond to conventional oxygen therapies.
ABSTRACT
To investigate the possible developmental programming, we analyzed the effects of maternal and postnatal low dose alpha-cypermethrin exposure on metabolic and redox parameters in the offspring. Postnatal changes in plasma biochemical parameters and plasma and tissue oxidative stress markers were determined in offspring of dams fed standard chow or diet containing alpha cypermethrin at 1.50mg/kg/day during gestation and lactation, weaned on to standard chow or on treated diet until adulthood (5months). Our results showed that exposure to alpha cypermethrin induced a significant reduction in body weight, food intake and metabolic alterations such as an increase in plasma glucose, triglyceride, urea, creatinine and AST levels in both postnatal and prenatal/postnatal treated female and male rats. This increase was more pronounced in prenatal/postnatal exposed rats. Alpha-cypermethrin exposure resulted in an imbalance of oxidant/antioxidant status, marked by high levels of carbonyl proteins and MDA, and low levels of antioxidants in erythrocytes, liver and kidney of both male and female offspring. Offspring of exposed dams have pre-existing oxidative stress that was accentuated with postnatal pesticide exposure. In conclusion, maternal alpha-cypermethrin exposure affected metabolism leading to permanent changes in biochemical parameters, enzyme activities and redox markers in the offspring. These abnormalities in offspring were worsened under postnatal pesticide exposure from weaning to adulthood.
Subject(s)
Animal Feed/adverse effects , Insecticides/metabolism , Insecticides/toxicity , Maternal Exposure/adverse effects , Prenatal Exposure Delayed Effects/etiology , Pyrethrins/metabolism , Pyrethrins/toxicity , Animal Feed/analysis , Animals , Blood Glucose/metabolism , Body Weight , Eating , Female , Lactation , Liver/drug effects , Liver/metabolism , Male , Oxidative Stress , Pregnancy , Prenatal Exposure Delayed Effects/metabolism , Prenatal Exposure Delayed Effects/physiopathology , RatsABSTRACT
Pyrethroid insecticides are extensively used in agriculture and in household activities. During pregnancy, they might affect maternal metabolic status and there after fetal development. In this work, we studied metabolic and redox effects of low dose alpha-cypermethrin exposure in pregnant rats and their offspring. The diet containing alpha cypermethrin at 0.02mg/kg/day was consumed during the entire gestation. Plasma biochemical parameters as well as liver lipid and oxidative stress markers were determined. Our results showed that alpha-cypermethrin induced an increase in body weight and in plasma glucose and lipid levels, as well as in plasma aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase activities in pregnant rats and their newborns. Pregnant rats showed cellular oxidative stress and altered oxidant-antioxidant status when treated by the insecticide and these disturbances were also seen in their newborns. In conclusion, low dose alpha-cypermethrin exposure induced several metabolic and redox alterations leading to maternal physiological impairments and to fetal metabolic changes. Alpha-cypermethrin should be used with caution especially during pregnancy.
