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Ann Chir ; 125(4): 376-9, 2000 May.
Article in French | MEDLINE | ID: mdl-10900741

ABSTRACT

The shortage of organ donors has led to progressive softening of selection criteria for organ donation. We report on hepatic transplantation in a 55-year-old woman with primary biliary cirrhosis, whose donor was a 50-year-old heart transplant recipient who became brain stem dead, due to cerebral bleeding 8 months after transplantation. An orthotopic liver transplantation was performed. The postoperative course was uneventful and the recipient was alive and had normal liver function after a 42-month follow-up. Analysis of the literature included ethical consideration, potential hepatotoxic effects of immunosuppressive drugs and modification of the graft immunogenicity. It confirms that transplanted patients should not be a priori excluded from organ donation.


Subject(s)
Brain Death , Heart Transplantation , Liver Transplantation , Cerebral Hemorrhage/complications , Ethics, Medical , Female , Follow-Up Studies , Humans , Immunosuppressive Agents/therapeutic use , Liver Cirrhosis, Biliary/surgery , Middle Aged , Tissue Donors
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