ABSTRACT
Lichen sclerosus is a chronic inflammatory disease of unknown origin, which affects mostly women in the fifth and sixth decades of life, but can also occur in men and children. The involvement of the oral mucosa alone or together with other forms of presentation is extremely rare, requiring a differential diagnosis with other diseases of the oral cavity, particularly lichen planus. There are less than 30 cases of lichen sclerosus in the oral mucosa described in the literature and there are no reports on malignant transformation so far. We describe a patient with skin, oral and genital lesions of lichen sclerosus.
Subject(s)
Genital Diseases, Female/diagnosis , Lichen Sclerosus et Atrophicus/diagnosis , Mouth Diseases/diagnosis , Administration, Topical , Aged , Diagnosis, Differential , Female , Genital Diseases, Female/drug therapy , Humans , Immunosuppressive Agents/administration & dosage , Lichen Sclerosus et Atrophicus/drug therapy , Mouth Diseases/drug therapy , Tacrolimus/administration & dosageABSTRACT
Malignant neurogenic mediastinal tumors in adults are uncommon and extremely aggressive. We report the case of a 61-year-old male patient with the simultaneous occurrence of malignant mediastinal schwannoma and bronchioloalveolar carcinoma. Although bronchioloalveolar carcinoma is present in 4-7% of the resected synchronous thoracic tumors, this association has never been reported in the literature. However, it is a common finding in patients presenting apparently inflammatory infiltrates and ground-glass opacities, as in the case presented here.
Subject(s)
Adenocarcinoma, Bronchiolo-Alveolar/pathology , Lung Neoplasms/pathology , Mediastinal Neoplasms/pathology , Neoplasms, Multiple Primary/pathology , Neurilemmoma/pathology , Adenocarcinoma, Bronchiolo-Alveolar/surgery , Fatal Outcome , Humans , Male , Mediastinal Neoplasms/surgery , Middle Aged , Neoplasms, Multiple Primary/surgery , Neurilemmoma/surgeryABSTRACT
Tumores neurogênicos malignos do mediastino em adultos são raros e extremamente agressivos. Este artigo relata o caso de um paciente de 61 anos com a ocorrência simultânea de schwannoma maligno de mediastino e carcinoma bronquíolo-alveolar. Apesar do carcinoma bronquíolo-alveolar estar presente em 4-7 por cento dos tumores torácicos sincrônicos ressecados, essa associação nunca foi apresentada na literatura. É, no entanto, um achado frequente em pacientes com infiltrados aparentemente inflamatórios e com opacidades em vidro fosco, como apresentado neste caso.
Malignant neurogenic mediastinal tumors in adults are uncommon and extremely aggressive. We report the case of a 61-year-old male patient with the simultaneous occurrence of malignant mediastinal schwannoma and bronchioloalveolar carcinoma. Although bronchioloalveolar carcinoma is present in 4-7 percent of the resected synchronous thoracic tumors, this association has never been reported in the literature. However, it is a common finding in patients presenting apparently inflammatory infiltrates and ground-glass opacities, as in the case presented here.