Interleukin-6 in two-stage revision arthroplasty: what is the threshold value to exclude persistent infection before re-implanatation?

The purpose of this study was to evaluate whether the serum level of interleukin 6 (IL-6) could be used to identify the persistence of infection after the first stage of a two-stage revision for periprosthetic joint infection. Between 2010 and 2011, we prospectively studied 55 patients (23 men, 32 women; mean age 69.5 years; 36 to 86) with a periprosthetic joint infection. Bacteria were identified in two intra-operative tissue samples during re-implantation in 16 patients. These cases were classified as representing persistent infection. To calculate a precise cut-off value which could be used in everyday clinical practice, a 3 x 2 contingency table was constructed and manually defined. We found that a serum IL-6 ≥ 13 pg/mL can be regarded as indicating infection: its positive-predictive value is 90.9%. A serum IL-6 ≤ 8 pg/mL can be regarded as indicating an absence of infection: its negative predictive value is 92.1%. The serum IL-6 level seems to be a reasonable marker for identifying persistent infection after the first stage of a revision joint arthroplasty and before attempting re-implantation.

Percutaneous CT-guided radio-frequency ablation of osteoid osteoma of the foot and ankle.

INTRODUCTION: Percutaneous radiofrequency ablation (RFA) has been considered, in recent years, the standard treatment for osteoid osteoma (OO) of the appendicular skeleton. The variable clinical presentations in the foot and ankle pose problems in diagnosis, localization and thus treatment. The aim of this study was to assess the efficacy of RFA for patients with osteoid osteoma of the foot and ankle. MATERIALS AND METHODS: A total of 29 patients (22 males, 7 females; mean age 16.7 years; range 8-44 years) with OO of the foot and ankle (distal tibia, n = 17; distal fibula, n = 6; talus, n = 3; calcaneus, n = 3) were enrolled in the study. A CT-guided RFA was performed, using a cool-tip electrode without the cooling system, heating the lesion up to 90 °C for 4-5 min. Clinical success, assessed at a minimum follow-up of 1 year, was defined as complete or partial pain relief after RFA. Pain and clinical outcomes were scored pre-operatively and at the follow-up with a visual analogue scale (VAS) and with the American Orthopaedic Foot and Ankle Society (AOFAS) score. Complications and local recurrences were also recorded. RESULTS: Clinical success was achieved in 26 patients (89.6 %). After RFA, mean VAS and AOFAS score significantly improved from 8 ± 1 to 2 ± 1 (p < 0.05) and from 60.7 ± 12.7 to 89.6 ± 7.1 (p < 0.05), respectively. Two patients experienced partial relief of pain and underwent a second successful ablation. Local recurrences were found in three patients, always associated with pain. These underwent conventional excision through open surgery. No early or late complications were detected after RFA. CONCLUSION: CT-guided RFA of foot and ankle osteoid osteoma is a safe and effective procedure, showing similar results for the rest of the appendicular skeleton.

[Endoprosthetic reconstruction of the proximal humerus in malignoma]. / Proximaler Humerusersatz bei malignen Schultergelenktumoren.

OBJECTIVE: The aim of the operation is local tumor control in malignant primary and secondary bone tumors of the proximal humerus. Limb salvage and preservation of function with the ability to lift the hand to the mouth. Stable suspension of the arm in the shoulder joint or the artificial joint. INDICATIONS: Primary malignant bone tumors of the proximal humerus or the scapula with joint infiltration but without involvement of the vessel/nerve bundle. Metastases of solid tumors with osteolytic defects in palliative or curative intention or after failure of primary osteosynthesis. CONTRAINDICATIONS: Tumor infiltration of the vessel/nerve bundle. Massive tumor infiltration of the soft tissues without the possibility of sufficient soft tissue coverage of the implant. SURGICAL TECHNIQUE: Transdeltoid approach with splitting of the deltoid muscle. Preparation and removal of the tumor-bearing humerus with exposure of the vessel/nerve bundle. Ensure an oncologically sufficient soft tissue and bone margin in all directions of the resection. Cementless or cemented stem implantation. Reconstruction of the joint capsule and fixation of the prosthesis using a synthetic tube. Soft tissue coverage of the prosthesis with anatomical positioning of the muscle to regain function. POSTOPERATIVE TREATMENT: Immobilization of the arm/shoulder joint for 4-6 weeks in a Gilchrist bandage. Passive mobilization of the elbow joint after 3-4 weeks. Active mobilization of the shoulder and elbow joint at the earliest after 4-6 weeks.

Intramedullary and total femur replacement in revision arthroplasty as a last limb-saving option: is there any benefit from the less invasive intramedullary replacement?

There has been a substantial increase in the number of hip and knee prostheses implanted in recent years, with a consequent increase in the number of revisions required. Total femur replacement (TFR) following destruction of the entire femur, usually after several previous revision operations, is a rare procedure but is the only way of avoiding amputation. Intramedullary femur replacement (IFR) with preservation of the femoral diaphysis is a modification of TFR. Between 1999 and 2010, 27 patients with non-oncological conditions underwent surgery in our department with either IFR (n = 15) or TFR (n = 12) and were included in this study retrospectively. The aim of the study was to assess the indications, complications and outcomes of IFR and TFR in revision cases. The mean follow-up period was 31.3 months (6 to 90). Complications developed in 37% of cases, 33% in the IFR group and 4% in the TFR group. Despite a trend towards a slightly better functional outcome compared with TFR, the indication for intramedullary femur replacement should be established on a very strict basis in view of the procedure's much higher complication rate.

The high tibial osteotomy, open versus closed wedge, a comparison of methods in 108 patients.

INTRODUCTION: One hundred and eight patients with varus gonarthrosis were treated with high tibial osteotomy (HTO) in 2001. Fifty one patients received an open wedge osteotomy by using the 'Puddu' plate and 57 patients received a Coventry-type closing wedge osteotomy. For both groups the follow-up examination period was 22.5 months (253-1009 days). MATERIAL AND METHODS: To evaluate the study, radiological and subjective criteria as well as the Lysholm and the Tegner Activity Score were used. Altogether 84 % of the patients were included in the follow-up examination study. RESULTS: In both groups a significant improvement of both scores were achieved. Both methods obtained safe and reproducible results for the correction considering the different operation techniques. There were no differences in outcome between the two methods. Satisfactory results were also achieved for early arthrosis of the femoropatellar and the lateral compartment. CONCLUSION: Open and closed wedge HTOs obtain significant improvement in patients with medial osteoarthritis of the knee. Using the right technique is very important for good results. For stabilization of the medial ligament we recommend the open wedge osteotomy. The patient should be informed about the routine removal of the metal plate.