ABSTRACT
PURPOSE: To analyze inflammatory parameters as possible predictors for the development of uveitis in juvenile idiopathic arthritis (JIA) patients. Further, to analyze the predictive value of demographic and clinical factors at the onset of arthritis. DESIGN: Retrospective cohort study. METHODS: In 358 children with oligoarthritis and rheumatoid factor-negative polyarthritis, erythrocyte sedimentation rate (ESR), C-reactive protein, leukocyte count, presence of antinuclear antibodies (ANA), presence of human leukocyte antigen (HLA-)B27, age of onset of JIA, and sex were analyzed for their predictive value for the onset of uveitis. RESULTS: One hundred forty-seven patients (41%) were diagnosed with chronic anterior uveitis. Young age of onset, presence of ANA, and elevated ESR appeared to be predictive factors according to univariate analyses (P = .029, P = .007, and P = 5E(-4), respectively). According to multivariate analysis, young age of onset and elevated ESR appeared to be predictive after adjusting for the other relevant factors (P = .004 and P = .001, respectively). A prediction model was developed. CONCLUSIONS: Elevated ESR appears to be a predictor for the occurrence of uveitis in patients with JIA. Since ESR is already routinely tested in patients with recently diagnosed arthritis, its use as a biomarker can easily be implemented in daily practice.
Subject(s)
Arthritis, Juvenile/blood , Biomarkers/blood , Uveitis/blood , Age of Onset , Antibodies, Antinuclear/blood , Blood Sedimentation , C-Reactive Protein/metabolism , Child , Child, Preschool , Cohort Studies , Female , HLA-B27 Antigen/blood , Humans , Infant , Leukocyte Count , Male , Retrospective StudiesABSTRACT
Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease and the most prevalent systemic disorder in children with uveitis. The current prevailing opinion is that JIA is a multifactorial, genetically predisposed autoimmune disorder that can be influenced by environmental factors and infections; the specific pathogenesis of JIA-associated uveitis is not understood, however, nor has the relationship between the eye and joint inflammation been established. Nevertheless, subtypes of JIA that are associated with uveitis, oligoarthritis, polyarticular rheumatoid factor negative, and psoriatic arthritis appear to have common pathogenicity. We summarize our current knowledge regarding the pathogenesis of JIA-associated uveitis and discuss the possible role of immune responses and cytokine involvement, genetic associations, and the influence of external triggers in this disease-an association that is supported by data obtained from arthritis research and experimental uveitis models.
Subject(s)
Arthritis, Juvenile/etiology , Uveitis, Anterior/etiology , Adolescent , Arthritis, Juvenile/immunology , Autoimmunity/physiology , Child , Child, Preschool , Humans , Infant , Uveitis, Anterior/immunologyABSTRACT
AIM: The long-term course of juvenile idiopathic arthritis (JIA)-associated uveitis is not known yet. This study investigates the course and activity of JIA-associated uveitis in childhood and puberty. DESIGN: Retrospective study of the clinical data of 62 JIA patients with uveitis. The main outcome measurements consisted of uveitis activity measured as mean cell grade in the anterior chamber, topical and systemic medication and ocular complications related to disease activity. All data were scored and evaluated per year of age. RESULTS: Uveitis activity took a biphasic course with a quiet phase around the age of 9 years and showed increased activity during early teenage years. The biphasic course was significantly related to age (p=0.048) but not to uveitis duration. More patients were treated with systemic immunosuppressive medication in estimated puberty years (63% in boys, 53% in girls) compared with prepuberty years (46% and 28%, respectively), although the difference was only significant in girls (p<0.001). The presence of cystoid macular oedema and papillitis was not significantly related to estimated puberty, but the development of an hypotonous eye was more frequently observed in boys in estimated puberty years (p=0.026). CONCLUSIONS: JIA-associated uveitis appears to take a biphasic course with the second phase of activity during early teenage years and more treatment with systemic immunosuppressive medication occurred during estimated puberty compared with prepuberty years.
Subject(s)
Arthritis, Juvenile/physiopathology , Puberty/physiology , Uveitis/physiopathology , Anterior Chamber/pathology , Arthritis, Juvenile/diagnosis , Arthritis, Juvenile/drug therapy , Child , Child, Preschool , Disease Progression , Female , Glucocorticoids/therapeutic use , Humans , Immunosuppressive Agents/therapeutic use , Infant , Male , Retrospective Studies , Uveitis/diagnosis , Uveitis/drug therapyABSTRACT
In 0.1% to 1% of cases cataract extraction is complicated by luxated lens fragments, also known as 'dropped nucleus'. Dropped nucleus can lead to severe complications such as glaucoma or retinal detachment. After incomplete cataract extraction visual acuity is poor. Although a few patients with dropped nucleus may heal with medication alone, pars plana vitrectomy is indicated in most of cases. Pars plana vitrectomy entails the removal of luxated lens fragments and placement of an artificial lens if necessary. It is recommended that pars plana vitrectomy be performed within one to two weeks after cataract extraction. It allows recovery of visual acuity in most of cases. It is important that cataract patients should be informed about the possibility of a dropped nucleus before the extraction.
