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AJR Am J Roentgenol ; 172(3): 709-12, 1999 Mar.
Article in English | MEDLINE | ID: mdl-10063865

ABSTRACT

OBJECTIVE: The purpose of this study was to describe our successful experience with high-dose intraarterial urokinase therapy in treating acute, life-threatening vertebrobasilar occlusion. CONCLUSION: We successfully treated five patients with acute vertebrobasilar occlusion who presented up to 24 hr after the onset of symptoms. Higher doses of urokinase than are commonly reported in the literature were used in this series at a rapid infusion rate with a "pulse-spray" technique. The result was prompt thrombolysis and good clinical outcome.


Subject(s)
Plasminogen Activators/administration & dosage , Urokinase-Type Plasminogen Activator/administration & dosage , Vertebrobasilar Insufficiency/drug therapy , Acute Disease , Adult , Humans , Infusions, Intra-Arterial/methods , Male , Plasminogen Activators/therapeutic use , Urokinase-Type Plasminogen Activator/therapeutic use , Vertebrobasilar Insufficiency/diagnosis , Vertebrobasilar Insufficiency/etiology
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