1.
Org Lett
; 11(14): 3140-2, 2009 Jul 16.
Article
in English
| MEDLINE
| ID: mdl-19527001
ABSTRACT
A novel method for the kinetic resolution of unsymmetrical acyclic allylic carbonates and the concurrent synthesis of enantioenriched secondary amines using a commercially available chiral catalyst is disclosed.
Subject(s)
Allyl Compounds/chemistry , Amines/chemical synthesis , Carbonates/chemistry , Rhodium/chemistry , Amines/chemistry , Catalysis , Molecular Structure , Stereoisomerism
2.
J Med Chem
; 51(21): 7010-4, 2008 Nov 13.
Article
in English
| MEDLINE
| ID: mdl-18921992
ABSTRACT
4-((1 R,2 R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile [PF-0998425, (-)- 6a] is a novel, nonsteroidal androgen receptor antagonist for sebum control and treatment of androgenetic alopecia. It is potent, selective, and active in vivo. The compound is rapidly metabolized systemically, thereby reducing the risk of unwanted systemic side effects due to its primary pharmacology. (-)- 6a was tested negative in the 3T3 NRU assay, validating our rationale that reduction of conjugation might reduce potential phototoxicity.