Iatrogenic pseudoaneurysm of the peroneal artery.

An elderly patient who presented with an acute lower limb ischaemia was managed by thromboembolectomy: this led to revascularisation of the lower limb but resulted in an iatrogenic pseudoaneurysm of the peroneal artery. Subsequent endovascular treatment was successful, and the patient has made a good recovery.

Quantifying the cadence of free-living walking using event-based analysis.

PURPOSE: Free-living walking occurs over a wide range of durations and intensities (cadence). Therefore, its characterisation requires a full description of the distribution of duration and cadence of these walking events. The aim was to use event-based analysis to characterise this in a population with intermittent claudication (IC) and a healthy matched control group. METHODS: Seven-day walking activity was recorded using the activPAL activity monitor in a group of people with IC (n=30) and an age-matched control group (n=30). The cadence, number of steps and duration of individual walking events were calculated and outcomes were derived, and compared (p<0.05), based on thresholds applied. RESULTS: Both groups had similar number of walking events per day (392±117 vs 415±160). The control group accumulated a greater proportion of their walking at higher cadences and 32% of their steps were taken at a cadence above 100 steps/min, for the IC group this was 20%. Longer walking events had higher cadences and the IC group had fewer of these. As walking events became longer the cadence increased but the inter-event cadence variability decreased. More purposeful walking might occur at a higher cadence, and be performed at a preferred cadence. Individuals with IC had a smaller volume of walking, but these differences occurred almost entirely above a cadence of 90 steps/min. CONCLUSIONS: This is the first study which has quantified the cadence of continuous periods of free-living walking. The characteristics (duration, number of steps and cadence) of all the individual walking events were used to derive novel outcomes, providing new insights into free-living walking behaviour.

MRI using ultrasmall superparamagnetic particles of iron oxide in patients under surveillance for abdominal aortic aneurysms to predict rupture or surgical repair: MRI for abdominal aortic aneurysms to predict rupture or surgery-the MA(3)RS study.

INTRODUCTION: Population screening for abdominal aortic aneurysms (AAA) halves the associated mortality and has led to the establishment of national screening programmes. Prediction of aneurysm growth and rupture is challenging and currently relies on serial diameter measurements with ultrasound. Recently, a novel MRI-based technique using ultrasmall superparamagnetic particles of iron oxide (USPIO) has demonstrated considerable promise as a method of identifying aneurysm inflammation and expansion. METHODS AND ANALYSIS: The MA(3)RS study is a prospective observational multicentre cohort study of 350 patients with AAA in three centres across Scotland. All participants will undergo MRI with USPIO and aneurysm expansion will be measured over 2 years with CT in addition to standard clinical ultrasound surveillance. The relationship between mural USPIO uptake and subsequent clinical outcomes, including expansion, rupture and repair, will be evaluated and used to determine whether the technique augments standard risk prediction markers. To ensure adequate sensitivity to answer the primary question, we need to observe 130 events (composite of rupture or repair) with an estimated event rate of 41% over 2 years of follow-up. The MA(3)RS study is currently recruiting and expects to report in 2017. DISCUSSION: This is the first study to evaluate the use of USPIO-enhanced MRI to provide additional information to aid risk prediction models in patients with AAA. If successful, this study will lay the foundation for a large randomised controlled trial targeted at applying this technique to determine clinical management. TRIAL REGISTRATION NUMBER: Current Controlled Trials: ISRCTN76413758.

Illness beliefs and walking behavior after revascularization for intermittent claudication: a qualitative study.

PURPOSE: Patients with peripheral artery disease (PAD) are recommended to increase physical activity to reduce cardiovascular risk. Vascular intervention (surgery or angioplasty) treats the symptom (intermittent claudication), but not the underlying cardiovascular disease. This study aims to explore the beliefs and physical activity behavior of patients with PAD who have received vascular intervention. METHODS: Twenty participants who had received a vascular intervention for intermittent claudication between 6 months and 2 years previously participated in semistructured interviews. The interviews explored illness and treatment beliefs and walking behavior. Data were transcribed verbatim and analyzed thematically. RESULTS: Participants described a high level of ongoing symptoms (particularly pain) in their legs, despite having received vascular intervention. They viewed their illness as acute and treatable, and believed that pain was an indication of walking causing damage. They controlled their symptoms by avoiding walking and slowing their pace. Participants were generally unaware of the causes of the disease and were unaware of their increased risk of future cardiovascular health problems. There was a low level of congruence between participant beliefs about their illness and the recommendation to increase physical activity that may affect physical activity behavior. CONCLUSIONS: Our findings suggest that patients with PAD do not change physical activity behavior after diagnosis and treatment, because they hold dysfunctional and incongruous beliefs about PAD, treatment, and physical activity.

Increasing walking in patients with intermittent claudication: protocol for a randomised controlled trial.

BACKGROUND: People with intermittent claudication are at increased risk of death from heart attack and stroke compared to matched controls. Surgery for intermittent claudication is for symptom management and does not reduce the risk of cardiovascular morbidity and mortality. Increasing physical activity can reduce claudication symptoms and may improve cardiovascular health. This paper presents the pilot study protocol for a randomised controlled trial to test whether a brief psychological intervention leads to increased physical activity, improvement in quality of life, and a reduction in the demand for surgery, for patients with intermittent claudication. METHODS/DESIGN: We aim to recruit 60 patients newly diagnosed with intermittent claudication, who will be randomised into two groups. The control group will receive usual care, and the treatment group will receive usual care and a brief 2-session psychological intervention to modify illness and walking beliefs and develop a walking action plan. The primary outcome will be walking, measured by pedometer. Secondary outcomes will include quality of life and uptake of surgery for symptom management. Participants will be followed up after (a) 4 months, (b) 1 year and (c) 2 years. DISCUSSION: This study will assess the acceptability and efficacy of a brief psychological intervention to increase walking in patients with intermittent claudication, both in terms of the initiation, and maintenance of behaviour change. This is a pilot study, and the results will inform the design of a larger multi-centre trial. TRIAL REGISTRATION: Current Controlled Trials ISRCTN28051878.