ABSTRACT
Human spleen, though being the largest component of reticuloendothelial system, is a very rare site of tumor metastases. Splenic metastases are usually seen as part of multi-organ involvement. Autopsy study conducted over a period of 10 years revealed that the incidence of neoplastic involvement of spleen was 1.45% (70/4812). Primary malignant involvement of spleen was also noted to be a rare entity in present study.
Subject(s)
Splenic Neoplasms/pathology , Splenic Neoplasms/secondary , Adenocarcinoma/pathology , Adenocarcinoma/secondary , Adolescent , Adult , Aged , Aged, 80 and over , Autopsy , Child , Child, Preschool , Female , Humans , Incidence , Lung Neoplasms/pathology , Lymphoma/pathology , Male , Middle Aged , Spleen/pathology , Splenic Neoplasms/epidemiologyABSTRACT
Fine-needle aspiration cytology (FNAC) of 32 HIV-positive cases presenting with lymphadenopathy was performed to evaluate its role in this group of patients. For each case air-dried smears were stained with Leishman, hematoxylin and eosin, and Zeihl-Neelsen stains for acid fast bacilli (AFB). The results were tuberculous (TB) lymphadenopathy (15), reactive lymphadenopathy (10), acute lymphadenitis/abscess (5), and suspected malignancy (2). In seven cases of TB lymphadenitis findings were suggestive of TB since no AFB was demonstrable on the cytology smears. In TB lymphadenitis, two additional patterns besides necrotising granulomatous (4) and granulomatous (2) were observed. These were necrotising (6) and necrotising suppurative (3) patterns. FNAC is a simple, inexpensive, rapid investigative procedure which can reduce surgical excisions and provide definite guidelines about further management.
Subject(s)
AIDS-Related Opportunistic Infections/pathology , Biopsy, Fine-Needle , HIV Infections/pathology , Lymph Nodes/pathology , Lymphatic Diseases/pathology , Adolescent , Adult , Female , HIV Infections/complications , Humans , Lymphatic Diseases/etiology , Male , Middle Aged , Tuberculosis, Lymph Node/complications , Tuberculosis, Lymph Node/pathologyABSTRACT
This is a case report of a mesenchymal tumor of uterus in a 60 year female initially interpreted as myxoid leiomyosarcoma. Immunohistochemical studies were negative for smooth muscle actin, desmin and p53 but positive for S-100 protein. The tumor was therefore reclassified as a low grade malignant mesenchymal tumor of neural origin.
