1.
J Pediatr Hematol Oncol
; 46(6): e448-e452, 2024 Aug 01.
Article
in English
| MEDLINE
| ID: mdl-39051638
ABSTRACT
Infection is a major cause of treatment-related morbidity and mortality in pediatric acute lymphoblastic leukemia (ALL). Most children with ALL who develop life-threatening bacterial infections do so during induction therapy. We describe a rare case of ALL presenting simultaneously with Streptococcus agalactiae group B Streptococcus bacteremia and meningitis in a 3-year-old girl. She received appropriate antimicrobial therapy and a 2-drug early induction regimen consisting of vincristine and dexamethasone, leading to slow neurologic recovery and a favorable initial response to anti-neoplastic therapy as evidenced by minimal residual disease of 1.12% on day 15 of induction.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols , Dexamethasone , Precursor B-Cell Lymphoblastic Leukemia-Lymphoma , Streptococcal Infections , Streptococcus agalactiae , Humans , Female , Child, Preschool , Streptococcal Infections/drug therapy , Streptococcal Infections/microbiology , Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy , Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/complications , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Dexamethasone/therapeutic use , Dexamethasone/administration & dosage , Meningitis, Bacterial/drug therapy , Meningitis, Bacterial/microbiology , Meningitis, Bacterial/diagnosis , Vincristine/administration & dosage , Vincristine/therapeutic use , Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy , Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications , Bacteremia/drug therapy , Bacteremia/microbiology
2.
Pediatr Blood Cancer
; 67(9): e28357, 2020 09.
Article
in English
| MEDLINE
| ID: mdl-32469139